| p38MAPK在纳洛酮减轻大鼠心肌缺血再灌注损伤中的作用 |
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| 引用本文： | 张探,周维东,夏安周,谷淑玲. p38MAPK在纳洛酮减轻大鼠心肌缺血再灌注损伤中的作用[J]. 华西药学杂志, 2011, 26(5): 460-462 |
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| 作者姓名： | 张探 周维东 夏安周 谷淑玲 |
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| 作者单位： | 1. 徐州医学院,江苏徐州,221004
2. 睢宁县人民医院,江苏睢宁,221200 |
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| 基金项目： | 徐州市科技发展基金(编号:XM08C117) |
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| 摘 要： | 目的 研究大鼠心肌缺血再灌注损伤后p38 MAPK的变化及纳洛酮对其的影响.方法SD大鼠24只随机均分为假手术组(sham)、缺血再灌注组(IR)、纳洛酮组(Nal).采用结扎左冠状动脉左前降支30 min,再灌注2h制作心肌缺血再灌注模型.观察心电图J点电位的变化；Western Bloting检测p38 MAPK、...
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| 关 键 词： | 纳洛酮 缺血再灌注 p38 MAPK 大鼠 |
Effect of p38 MAPK on naloxone alleviating myocardial ischemia reperfusion injury in rats |
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| ZHANG Tan , ZHOU Wei-dong , XIA An-zhou , GU Shu-ling. Effect of p38 MAPK on naloxone alleviating myocardial ischemia reperfusion injury in rats[J]. West China Journal of Pharmaceutical Sciences, 2011, 26(5): 460-462 |
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| Authors: | ZHANG Tan ZHOU Wei-dong XIA An-zhou GU Shu-ling |
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| Affiliation: | ZHANG Tan1,ZHOU Wei-dong2,XIA An-zhou1,GU Shu-ling1* (1.Department of pharmacology,Xuzhou Medical college,Xuzhou,Jiangsu,221004 P.R.China,2.Department of Anesthesiology,the People's Hospital of Suining,Suining,221200 P.R.China) |
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| Abstract: | OBJECTIVE To investigate the change of p38 MAPK after myocardial ischemia reperfusion injury in rats and the effects of naloxone.METHODS Twenty-four SD rats were randomly divided into three groups.sham-operated group,IR group,IR and treated with Naloxone group.The myocardial ischemia reperfusion injury model was established by ligating the left anterior descending coronary artery for 30 minutes followed by reperfusion for 2 h.ECG was used to detect J dot changes.Terminal deoxynucleotidy transferase mediated... |
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| Keywords: | Naloxone Ischemia reperfusion p38 MAPK Rat |
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