| 双黄连口服制剂中连翘有效成分的吸收调控 |
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| 引用本文： | 李芸霞,朱红云,蒋学华. 双黄连口服制剂中连翘有效成分的吸收调控[J]. 华西药学杂志, 2011, 26(5): 411-413 |
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| 作者姓名： | 李芸霞 朱红云 蒋学华 |
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| 作者单位： | 1. 成都中医药大学药学院教育部中药材标准化重点实验室 中药资源系统研究与开发利用省都共建国家重点实验室培育基地,四川成都,610075
2. 四川大学华西药学院,四川成都,610041 |
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| 基金项目： | 国家自然科学基金资助项目(批准号:30070935;30271614) |
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| 摘 要： | 目的 研究双黄连口服制剂中连翘有效成分的吸收调控.方法采用HPLC法测定大鼠在体实验中连翘苷和连翘酯苷的含量,采用大鼠在体肠实验方法分别进行了整方和拆方的研究.结果连翘苷几乎无吸收.绿原酸能显著改善连翘酯苷在大鼠体内的吸收速度和程度.结论双黄连制剂中,金银花能显著改善连翘酯苷的吸收,提示中药组方的合理性.
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| 关 键 词： | 连翘苷 连翘酯苷 双黄连口服制剂 吸收调控 |
Study on the absorption modulation of phillyrin and forsythiaside in Shuanghuanglian oral preparations |
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| LI Yun-xia , ZHU Hong-yun , JIANG Xue-hua. Study on the absorption modulation of phillyrin and forsythiaside in Shuanghuanglian oral preparations[J]. West China Journal of Pharmaceutical Sciences, 2011, 26(5): 411-413 |
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| Authors: | LI Yun-xia ZHU Hong-yun JIANG Xue-hua |
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| Affiliation: | LI Yun-xia1,ZHU Hong-yun1,JIANG Xue-hua2* (1.Pharmacy College,Chengdu University of Traditional Chinese Medicine,The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine,State Key Laboratory Breeding Base Co-Constructed by Ministry of Science and Technology and Province Department of Systemically Research and Exploitation of Chinese Medicine Resources,Chengdu,Sichuan,610075 P.R.China,2.West China School of Pharmacy,Sichuan University,610041 P.R.China) |
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| Abstract: | OBJECTIVE To study the absorption characters and mechanism of phillyrin and forsythiaside in Shuanghuanglian oral preparations.METHODS The concentration of phillyrin and forsythiaside were determined by HPLC,the absorption mechanism was investigated by using an in situ intestine experiment model.RESULTS The concentration of phillyrin in perfusion solution changed little which indicated that the compositions in Shuanghuanglian oral preparations could not improve the absorption of phillyrin.But the absorption... |
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| Keywords: | Phillyrin Forsythiaside Shuanghuanglian oral preparations Absorption modulation |
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