| 马尼地平缓释微丸胶囊的制备及体外释放度考察 |
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| 引用本文： | 于波涛,范开华,向清宇,邓岚,李绍菊.马尼地平缓释微丸胶囊的制备及体外释放度考察[J].华西药学杂志,2011,26(5):429-432. |
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| 作者姓名： | 于波涛 范开华 向清宇 邓岚 李绍菊 |
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| 作者单位： | 1. 成都军区总医院药剂科,四川成都,610083
2. 成都医学院药学系,四川成都,610083 |
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| 摘 要： | 目的 制备马尼地平缓释微丸胶囊并考察其体外释放度.方法采用喷雾包衣制备载药微丸,选用羟丙基甲基纤维素、乙基纤维素作为包衣缓释材料进行缓释包衣.采用单因素筛选法,考察包衣液的比例、包衣增重、溶出介质等因素对缓释微丸释放度的影响.采用HPLC法测定主药含量,并计算其体外释放度.结果当羟丙基甲基纤维素与乙基纤维素的比例为7∶...
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| 关 键 词： | 马尼地平 缓释微丸 喷雾包衣 体外释放度 |
Preparation and in vitro release study of Manidipine sustained-release pellets capsules |
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| YU Bo-tao
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FAN Kai-hua
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XIANG Qing-yu
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DENG Lan
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LI Shao-ju.Preparation and in vitro release study of Manidipine sustained-release pellets capsules[J].West China Journal of Pharmaceutical Sciences,2011,26(5):429-432. |
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| Authors: | YU Bo-tao FAN Kai-hua XIANG Qing-yu DENG Lan LI Shao-ju |
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| Institution: | YU Bo-tao1,FAN Kai-hua1,XIANG Qing-yu1,DENG Lan2,LI Shao-ju2 (1.General Hospital of Chengdu Military Command,Chengdu,Sichuan,610083 P.R.China,2.Chengdu Medical College,610083 P.R.China) |
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| Abstract: | OBJECTIVE To prepare Manidipine sustained-release pellets capsules and investigate its release behavior in vitro.METHODS Manidipine drug-loaded pellets were prepared by spray-coated method.HPMC and EC were selected as the sustained-release coating material.The single factor design was applied to investigate the effects of the ratio of HPMC to EC,the coating weight,and the dissolution media on the release rate of the pellets.The concentration release rate of Manidipine was determined by HPLC.RESULTS When the... |
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| Keywords: | Manidipine Sustained-release pellets Spray coating In vitro release |
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