| 小鼠双微体扩增基因反义寡核苷酸在血管平滑肌细胞中的摄取动力学研究 |
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| 引用本文： | 付鹏,韩巍,姜廷军,赵长久,尹雪松. 小鼠双微体扩增基因反义寡核苷酸在血管平滑肌细胞中的摄取动力学研究[J]. 哈尔滨医科大学学报, 2011, 45(5): 405-408 |
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| 作者姓名： | 付鹏 韩巍 姜廷军 赵长久 尹雪松 |
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| 作者单位： | 1. 哈尔滨医科大学附属第四医院核医学科
2. 急诊科,黑龙江哈尔滨,150001 |
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| 基金项目： | 黑龙江省教育厅科学技术研究项目(11531192) |
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| 摘 要： | 目的 研究小鼠双微体扩增基因( mouse double minute 2,mdm2)反义寡核苷酸(antisense oligonucleotide,ASON)在血管平滑肌细胞中的摄取动力学,探讨mdm2反义寡核苷酸包埋支架防治支架内再狭窄的可行性.方法 人工合成一段针对mdm2 mRNA的反义寡核苷酸,以肼基尼古...
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| 关 键 词： | 小鼠双微体扩增基因 平滑肌细胞 寡核苷酸 脂质体 |
Research of mdm2 antisense oligonucleotide of the uptake kinetics in vascular smooth muscle cells |
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| FU Peng,HAN Wei,JIANG Ting-jun,ZHAO Chang-jiu,YIN Xue-song. Research of mdm2 antisense oligonucleotide of the uptake kinetics in vascular smooth muscle cells[J]. Journal of Harbin Medical University, 2011, 45(5): 405-408 |
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| Authors: | FU Peng HAN Wei JIANG Ting-jun ZHAO Chang-jiu YIN Xue-song |
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| Affiliation: | FU Peng1,HAN Wei1,JIANG Ting-jun1,ZHAO Chang-jiu1,YIN Xue-song2(1.Department of Nuclear Medicine,2.Department of Emergency,The Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China) |
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| Abstract: | Objective To investigate the possibility of using mdm2 mRNA antisense oligonucleotide(ASON)on preventing restenosis following angioplasty,the uptake kinetics of the mdm2 ASON in vascular smooth muscle cells.Methods An ASON targeted to mdm2 mRNA were synthesized and radiolabeled by 99Tcm with the bifunctional chelator HYNIC.The uptake kinetics of the liposome-coated antisense oligonucleotide were studied in vascular smooth muscle cells at different times,compared with those of the non-coated ASON in vascular... |
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| Keywords: | mouse double minute 2 smooth muscle cells oligonucleotide liposome |
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