肥大细胞在胃癌及癌前病变组织中的分布及其临床意义

目的:观察肥大细胞(MC)在胃良性病变、胃癌前病变及胃癌组织中的分布,并探讨其临床意义。方法:采用免疫组化方法标记23例胃癌组织、30例胃癌前病变组织和12例胃良性病变组织中的MC,观察其分布并计数,探讨其与临床病理资料的关系。结果:胃癌前病变组MC数高于胃癌组、胃良性病变组(P<0.05)。胃癌前病变及胃癌组中,幽门螺旋杆菌(HP)阳性组织中MC数多于HP阴性组织者(P<0.05),且MC与其余临床病理特征无相关性。结论:MC可能参与了胃癌的早期病变过程,尤其是与HP感染诱发的胃癌或癌前病变的发生可能存在密切关系。

Distribution and clinical significance of mastocyte in gastric cancer and precancerous lesion tissues

Objective:To observe the distribution of mast cells( MC) in gastric benign lesion tissues,gastric precancerous lesion tissues and gastric cancerous tissues,and to explore its clinical significance. Methods:Immunohistochemical method was used to mark and count MC in 23 gastric benign lesion tissues,30 gastric pre-cancerous lesion tissues and 12 gastric cancerous tissues. The distribu-tion of MC was observed and its relationship with clinical pathological data was explored. Results:The MC count in gastric precancerous lesion group was evidently higher than that either in gastric cancer group or in gastric benign lesion group(P<0. 05),and the MC count in helicobacter pylori( HP) positive tissues was also markedly higher than that in HP negative tissues both in gastric precancerous lesion group and in gastric cancer group(P<0. 05 or P<0. 01). However,there was no significant correlation between MC count and other pathological characteristics(P>0. 05). Conclusion:MC may have participated in the early lesion of gastric cancer,and there is poten-tial close association between MC and HP-induced gastric cancer and precancerous lesion.