高尿酸血症及痛风性关节炎动物模型及其中药复方治疗概况

痛风是嘌呤代谢紊乱和/或尿酸排泄减少而致血尿酸水平升高,尿酸盐(monosodium urate,MSU)晶体沉积于组织或器官并引起组织损伤的一组临床综合征,主要表现为反复发作性关节红、肿、热、痛与功能障碍,甚至关节畸形、肾石病及尿酸性肾病。高尿酸血症是痛风发生的生化基础。流行病学显示痛风的发病率在世界范围内呈逐年上升趋势。高尿酸血症/痛风严重危害人类健康,对于其发生发展机制的研究以及相关药物治疗的研究越来越受到科研工作者的重视。因此,对于高尿酸血症、痛风性关节炎动物模型的研究以及中药复方制剂在高尿酸血症/痛风中疗效的研究正如雨后春笋般如火如荼,它将从高尿酸血症、痛风性关节炎动物模型的研究及中药复方制剂在高尿酸血症/痛风中疗效的研究现状及概况做一综述。

Overview of the animal model of hyperuricemia and gouty arthritis and treatment of tradition Chinese medicine compound

Gout is a group of clinical syndrome caused by tissues damage,resulting from purine metabolic disorder and/or de-creasing uric acid excretion that cause blood uric acid levels to increase,and ( monosodium urate ( MSU) crystal to deposit in tissues or organs. The main symptoms of gout mainly include recurrent joint redness,swelling,heat,pain and dysfunction,even joint deformities, nephrolithiasis,and hyperuricaemia. Hyperuricaemia is a risk factor for gout. Epidemiological data show that the incidence of gout is in-creasing in the world. Since hyperuricemia/gout has been threatening people’s health,more attention of the researchers has been focus on the study of its development mechanism and the experiments of drugs. Therefore,the experiments of animal models and treatments and the studies of traditional Chinese compound medicine used to treat hyperuricemia and gouty arthritis have been developing like the bamboo shoots after the rain. The article will summarize the studies of the animal model and treatment and the curative effects of tradi-tional Chinese compound medicine on hyperuricemia and gouty arthritis.