原发性高血压病患者血压昼夜节律的临床意义探讨

目的 探讨原发性高血压病患者昼夜血压均值波动的节律与临床意义。方法 ９２例原发性高血压病人分成三组，单纯收缩压增高组（ＩＳＨ）３６例，收缩压和舒张压均增高认定为混合组（ＭＤＨ），共３１例，二组均除外心，脑，肾损害。高血压合并左心室肥大（ＬＶＨ）组２５例。２０例正常个体为对照组，仪器采用美国Ｓｐａｃｅｌａｂｓ ９０２０７无创性携带式血压监测仪，获取２４小时平均收缩压（２４ｈＳＢＰ０和舒张压（２４ｈＤ

Clinical significance of circadian blood pressure changes in patients with essential hypertension

Objectives To study the clinical significance of circadian blood pressure(BP) changes in patients with essential hypertension.Methods Ninety-two patients with essential hypertension were divided into three groups.ISH group included 36 patients with isolated systolic hypertension.MDH group consisted of 31 patients with both systolic and diastolic hypertension.None of them had cardiac,cerebral or renal impairment due to hypertension.LVH group embodied 25 patients with essential hypertension accompany left ventricular hypertrophy.Twenty normal subjects were enrolled as control group.Spacelabs 90207 noninvasive portable BP monitor was employed to obtain 24-hour systolic BP(24hSBP),24-hour diastolic BP (24hDBP),nocturnal systolic BP (nSBP),nocturnal diastolic BP (nDBP),daytime systolic BP (dSBP),daytime diastolic BP (dDBP),nSBP/dSBP,and nDBP/dDBPResults (1)Both normal subjects and patients with essential hypertension ISH and MDH have circadian BP variations.LVH loss of circadian rhythm in blood pressure.(2)The 24hSBP,dSBP and nSBP in ISH group,MDH group and LVH group are higher than controls.(3)the nDBP/dDBP in MDH group and LVH group are higher than controls.(4)The nSBP/dDBP is significantly different btween the LVH and controls.Conclusions If ISH and MDH patients have no target organ impairment,their nSBP/dSBP is not different from that of normal subjects,but LVH is increase.nSBP/dSBP could used to predict target organ impairment.