质子泵抑制剂在反流性食管炎维持治疗中的效果

目的研究质子泵抑制剂在反流性食管炎维持治疗的临床疗效。方法将2009年3月12月门诊及住院的121例反流性食管炎并胃镜证实病灶已愈合,且停药1周内症状又复发者,随机分为A、B、C3组,3组均选用兰索拉唑。A组为兰索拉唑15mg,1次/d,早餐前服;B组为兰索拉唑15mg,1次/d,晚餐前服;C组兰索拉唑15mg,2次/d,餐前服。3组疗程均为4周。疗程结束后进行临床症状疗效评定,并予复查胃镜,评价3组胃镜下总有效率,并观察3组不良反应。结果三种方案有效率分别为77.5%、95.0%、92.7%。结论晚餐前15mg1次/d的兰索拉唑为反流性食管炎较佳维持治疗方案。

Clinical Effect of Maintenance Therapy with Proton Pump Inhibitor in Reflux Esophagitis

Objective To investigate the clincal effect of proton pump inhibitor for maintenance of treatment of reflux esophagitis. Methods From March to December 2009, 121 recrudescent patients with gastroscope proved in one week of reflux esophagitis were randomized divided into 3 groups. All patients were given with lansoprazole, Scheme A （15 mg po, qd） before breakfast; Scheme B （15 mg, po, qd ） after supper and Scheme C （15 mg, po, bid） before food. Course of treatment was four weeks. After the treatment, clinical efficacy was evaluated and the total effective rate was evaluated by gastroscopy. Adverse reactions were also observed. Results The effective rates of three groups were 77.5%, 95.0%, and 92.7% respectively. Conclusion Lansoprazole by one dose of 15 mg after supper is a better maintenance treatment for reflux esophagitis.