寻常型银屑病生长抑素和表皮生长因子研究

目的探讨生长抑素（somatostatin,SS）和表皮生长因子（epidermal growth factor,EGF）在银屑病治疗中的相互作用机制。方法选择2008年1月-12月门诊和住院的寻常型银屑病患者68例,用放射免疫法检测正常组织和各期银屑病皮损中SS和EGF的表达。结果进行期银屑病皮损中EGF明显高于静止期、恢复期皮损和正常皮肤（P〈0.01）;各期银屑病皮损与正常皮肤中SS差异无统计学意义（P〈0.05）。结论SS可能是通过抑制EGF而在银屑病的治疗中起关键作用。

Detection of Somatostatin and Epidermal Growth Factor in Psoriatic Lesions

Objective To explore the treatment mechanism of somatostatin（SS）and epidermal growth factor（EGF）in psoriasis vulgaris.Methods Expression of SS and EGF was detected in normal skin tissues and psoriatic lesions by radioimmunoassay from January to December 2008.Results Expression of EGF was significant enhanced in active psoriasis than in stable,recovery patients and normal ones（P〈0.01）.There was no significant difference in SS expression between psoriatic lesions and normal controls（P〉0.05）.Conclusion SS may play an important role in therapy of psoriasis by inhibiting the expression of EGF.