Signaling via LTbetaR on the lamina propria stromal cells of the gut is required for IgA production |
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Authors: | Kang Hyung-Sik Chin Robert K Wang Yang Yu Ping Wang Jun Newell Kenneth A Fu Yang-Xin |
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Institution: | Department of Pathology and Committee on Immunology, The University of Chicago, 5841 S. Maryland, Chicago, IL 60637, USA. |
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Abstract: | Peyer's patches (PPs) and/or mesenteric lymph nodes (MLNs) are thought to be essential for immunoglobulin A (IgA) production. We found that the severe IgA deficiency in lymphotoxin-deficient (LT(-/-)) mice could be fully reversed by reconstitution with LT-expressing bone marrow, despite the absence of both LNs and PPs. The number of IgA precursors from LT(-/-) mice was not reduced, and they were able to migrate into the lamina propria (LP) of wild-type mice but not of LTbetaR(-/-) mice. Consistently, lymphoid tissue chemokines and adhesion molecules were reduced within the LP of LTalpha(-/-) and LTbetaR(-/-) mice. IgA deficiency in LTalpha(-/-) mice was reversed by the transplantation of a segment of RAG-1 (recombination-activating gene 1) deficient intestine, which confirmed the dispensability of the MLNs and PPs and the sufficiency of the LT-mediated gut microenvironment for IgA production. |
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