| 复方甲磺酸帕珠沙星滴眼液的制备及质量控制 |
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| 引用本文： | 詹峰,李金伟,何西奎,谭屹.复方甲磺酸帕珠沙星滴眼液的制备及质量控制[J].中国实用医药,2009,4(4):52-53. |
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| 作者姓名： | 詹峰 李金伟 何西奎 谭屹 |
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| 作者单位： | 1. 河南省郑州市中心医院,450007
2. 郑州市人民医院 |
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| 摘 要： | 目的制备复方甲磺酸帕珠沙星滴眼液,并建立质量控制方法。方法以甲磺酸帕珠沙星、氯化钠、地塞米松磷酸钠、羟苯乙酯制备复方甲磺酸帕珠沙星滴眼液;采用高效液相色谱法测定其中甲磺酸帕珠沙星的含量。结果甲磺酸帕珠沙星检测浓度在20.0～80.0μg/ml范围内线性关系良好（r=0.9999）,平均回收率为97.7%（RSD=1.96%,n=6）。结论本方法简便？准确？重现性好,可用于甲磺酸帕珠沙星滴眼液的质量控制。
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| 关 键 词： | 甲磺酸帕珠沙星 滴眼液 制备 质量控制 |
Preparation and quality control of compound pazufloxacin mesilate eye drops |
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| Institution: | ZHAN Feng, LI Jin-wei, HE Xi-kui ,et al. (Zhengzhou Hospital of Traditional Chinese Medicine ,Zhengzhou City, Henan 450007, China) |
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| Abstract: | Objective To prepare compound pazufloxacin mesilate eye drops and a to establish a method of it’s qualit control.Methods Compound pazufloxacin mesilate eye drops were parepared with pazufloxacin mesilate,sodium chloride,dexamethasone sodium phosphate,and ethylparaben.The content of moxifloxacin h drochloride was d etermined by HPLC.Results A linear calibration curve for assay of Pazufloxacin mesilate was obtained in the range of 20.0～80.0 μg/ml（r=0.999 9） and the average recoveries were 97.7%（RSD=1.96% n=6）.Conclusion Formation technique is simple and quality can be controled,thus deserving to be popularized. |
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| Keywords: | Pazufloxacin mesilate Eye drops Preparation Quality control |
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