异甘草酸镁治疗重度戊型黄疸性肝炎患者的疗效观察

目的分析观察异甘草酸镁治疗戊型肝炎重度黄疸的疗效。方法选择2009年1月至2012年12月收治的戊型肝炎重度黄疸患者78例,同比例分为治疗组和对照组,每组各39例,2组均给予多烯磷脂酰胆碱、还原型谷胱甘肽、能量合剂保肝,治疗组加用异甘草酸镁注射液150 mg静滴,1次/d,而对照组则加用复方甘草酸苷注射液120 mg静滴1次/d,两组疗程均为6周。TBil85μmol/L,ALT160 U/L为主要有效指标。两组间均数采用成组t检验,组内治疗前后比较采用配对t检验,计数资料组间比较用χ2检验。结果两组患者治疗后均有好转,治疗组的总有效率为84.6%(33/39),优于对照组66.7%(26/39),差异有统计学意义(P0.05)。且治疗组的TBil为(68.9±40.3)μmol/L,恢复显著优于对照组(129.1±69.3)μmol/L,其中各组F值为:24.658、36.145,χ2值为12、15,P0.01,差异有统计学意义。结论异甘草酸镁治疗戊型肝炎重度黄疸疗效显著,一定药物浓度范围内对肝细胞增殖有明显的促进作用,加速黄疸消退,无明显不良反应。

Efficacy of magnesium isoglycyrrhizinate in treatment of hepatitis E with severe jaundice

Objective To observe and analyze the efficacy of magnesium isoglycyrrhizinate in the treatment of hepatitis E with severe jaun-dice.Methods Seventy-eight cases of hepatitis E with severe jaundice admitted from January 2009 to December 2012 were equally divid-ed into treatment group （n=39 ）and control group （n=39 ）.Both groups were given polyene phosphatidylcholine,reduced glutathione, and Adenosine Disodiu for liver protection;additionally,magnesium isoglycyrrhizinate injection （150 mg）was given to the treatment group by intravenous drip once daily,while compound glycyrrhizin injection （120 mg）was given to the control group by intravenous drip once dai-ly.The course of treatment was 6 weeks in the two groups.Patients were considered to show response to treatment if their serum levels of to-tal bilirubin （TBil）and alanine aminotransferase were 〈85 μmol/L and 〈160 U/L,respectively.Comparison of means between the two groups was made by independent-samples t test;before-after comparison within each group was made by paired t-test;comparison of e-numeration data between the two groups was made by chi -square test.Results Both groups showed improvements after treatment.The treatment group had a significantly higher overall response rate than the control group （84.6%vs 66.7%,P〈0.05）.After treatment,the treatment group had a serum TBil level of 68.9 ±40.3 μmol/L,with significantly more improvement compared with the serum TBil level for control group （129.1 ±69.3 μmol/L）（F=24.658,χ2 =12,P〈0.01;F=36.145,χ2 =15,P〈0.01）.Conclusion Magnesium iso-glycyrrhizinate has significant efficacy in the treatment of hepatitis E with severe jaundice.It shows a marked promotional effect on the prolif-eration of liver cells within a certain concentration range,accelerates jaundice disappearance,and has no obvious adverse effects.