HBV/HCV重叠感染的研究进展 |
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引用本文: | 何丽,胡萍,申焕君,张野,黄长形. HBV/HCV重叠感染的研究进展[J]. 临床肝胆病杂志, 2014, 0(6): 569-572 |
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作者姓名: | 何丽 胡萍 申焕君 张野 黄长形 |
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作者单位: | 何丽 (第四军医大学唐都医院 传染科,西安,710038); 胡萍 (第四军医大学唐都医院 传染科,西安,710038); 申焕君 (第四军医大学唐都医院 传染科,西安,710038); 张野 (第四军医大学唐都医院 传染科,西安,710038); 黄长形 (第四军医大学唐都医院 传染科,西安,710038); |
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基金项目: | 国家自然科学基金资助项目(81072434);国家“十一五”科技重大专项(项目编号:2008ZX10002-006) |
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摘 要: | HBV是一种嗜肝DNA病毒,HBV DNA和HBV特异P蛋白由核壳包裹成为核心颗粒,再由脂蛋白外膜包裹成完整的病毒颗粒。HCV是黄病毒科病毒,为单股正链RNA。HBV和HCV均由肠道外途径传播,2种病毒常可由相同途径发生感染。归纳了HBV/HCV重叠感染的发病机制、与隐匿性HBV感染和肝细胞癌以及器官移植、HBV疫苗之间的关系,同时介绍了重叠感染的治疗。指出存在于患者体内的HBV和HCV在病毒学方面相互干扰,在病变方面相互叠加。
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关 键 词: | 乙型肝炎病毒 丙型肝炎病毒 重叠感染 乙型综述 |
Research progress in HBV/HCV co-infection |
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Affiliation: | HE Li , HU Ping, SHEN Huanjun, et al. ( Department of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi' an 710038, China) |
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Abstract: | Hepatitis B virus (HBV)is a hepatotropic DNA virus;HBV DNA and special P protein are covered by capsid proteins to form core particles,which are then covered by lipoprotein to form complete virus particles.Hepatitis C virus (HCV),which belongs to the Flavi-viridae family,is a single-stranded,positive-sense RNA.HBV and HCV are transmitted by parenteral route and may cause co-infection through the same route of transmission.The pathogenesis of HBV/HCV co-infection and its relationship with occult HBV infection,hepato-cellular carcinoma,organ transplantation,and HBV vaccine are reviewed.Meanwhile,the treatment of co -infection is presented.It is shown that HBV and HCV interfere with each other in terms of virology and pathology. |
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Keywords: | hepatitis B virus hepatitis C virus superinfection review |
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