血清CYFRA21-1、CA125及CA72-4对食管癌的诊断价值

目的 探讨血清CYFRA21-1、CA72-4、CA125对食管癌的诊断价值.方法 采用放射免疫分析法检测79名正常健康对照者、238例食管癌患者血清CA125、CA72-4和CYFRA21-1的水平.结果 对食管癌患者组,CYFRA21-1的界值为1.8ng/mL时,其敏感性、特异性等优于其他界值.三种肿瘤标志物CYFRA21-1、CA72-4和CA125阳性检出率分别为49.16％、30.89％、13.81％.多种肿瘤标志物联合检测中,CYFRA21-1和CA72-4联检,阳性检出率为65.00％,CYFRA21-1和CA125联检,阳性检出率为47.56％,CA125和CA72-4联检,阳性检出率为31.00％.结论 食管癌患者组CYFRA21-1的界值为1.8ng/mL时,三种肿瘤标志物中CYFRA21-1对食管癌患者的阳性率优于CA125及CA72-4;CYFRA21-1和CA72-4联合检测优于其他两种肿瘤标志物联合检测.

Diagnosis Value of Serum CYFRA21-1, CA125 and CA72-4 in Esophageal Cancer

Objective To investigate the diagnosis value of the serum levels of CA125,CA72-4 and CYFRA21-1 in patients with esophageal patients.Methods The serum levels of CA125,CA72-4 and CYFRA21-1 in 320 esophageal patients and 79 healthy controls were measured by radioimmunoassay.Results When the cut-off values of serum CYFRA21-1 was 1.8ng/mL,the clinical significant is better than other cut-off.The levels of CYFRA21-1,CA-72-4 and CA125 in esophageal patients were significant higher than that of healthy controls （P 〈0.01）.The positive rate of CYFRA21-1,CA72-4 and CA125 in esophageal patients were 49.16%,30.89% and 13.81% respectively.The positive rate of combination of CYFRA21-1 and CA72-4 was 65%,and that of combination of CYFRA21-1 and CA125 was 47.56%,that of combination of CA125 and CA72-4 was 31.00%.Conclusion The combined detection of CYFRA21-1 and CA72-4 are super than other two tumor markers.