甲状旁腺激素和甲状旁腺99Tcm-MIBI显像联合应用在慢性肾功能衰竭诊治中的价值

目的 了解甲状旁腺激素和甲状旁腺99Tcm-MIBI显像联合应用在慢性肾功能衰竭诊治中的价值.方法 对我院83名慢性肾功能衰竭（CRF）患者检测血清PTH及血清Ca、磷（P）含量并进行甲状旁腺显像.结果 慢性肾功能衰竭组患者血清PTH含量明显高于健康对照组,差异有统计学意义（P＜0.01）;且慢性肾功能衰竭组患者的血清Ca、P含量与健康对照组比较差异有统计学意义（P＜0.05）.83名慢性肾功能衰竭患者双时相99Tcm-MIBI甲状旁腺显像中,69名患者发现甲状旁腺增生病灶72个（3名有两个增生灶,66名有1个增生灶）.结论 慢性肾功能衰竭患者中检测血清PTH含量可以及时了解病情对症下药,并对判断疗效及预后有重要意义,同时通过甲状旁腺显像明确诊断并通过术前显像定位增生病灶指导外科医生手术治疗.

Clinical Value of Combined Application of PTH Measurement and 99Tcm-sestamibi Imaging in Diagnosis of Chronic Renal Failure

in diagnosis To explore the value of combined application of PTH measurement and 99Tcm-sestamibi of chronic renal failure. Methods 83 patients of chronic renal failure in our hospital were selected for measurement serum levels of PTH, Ca and P and for parathyroid imaging. Results The serum levels of PTH in patients in chronic renal failure were obviously higher than that of healthy controls （P 〈 0.01 ）. There were significant difference on the serum levels of Ca and P between patients with chronic renal failure and healthy controls （ P 〈 0.05 ）. In dual-phase 99Tcm - MIBI parathyroid imaging for 83 patients with chronic renal failure,72 lesions of parathyroid hyperplasia were found in 69 patients （3 patients had 2 hyperplasia lesions and 66 patients had 1 hyperplasia lesion）. Conclusion The detection of serum PTH in patients with chronic renal failure could help in understanding patient＇s condition and providing corresponding treatment, which is also significant in evaluation of curative effect and prognosis. The parathyroid imaging before surgery can be adopted to identify diagnosis and providing guidance for surgery treatment through location to lesion.