优甲乐干预131I治疗甲亢后早发甲减的观察

目的 用不同剂量的优甲乐（L-T4）干预^131I治疗甲亢后对早发甲减的影响.方法 218例Graves病患者,按照随机分组分为3组,A组69例,单纯给予^131I治疗作为对照组;B组78例,^131I治疗后21天起用L-T4 25 μg/d连续治疗20天;C组71例,^131I治疗后21天起用L-T4 100 μg/d连续治疗20天;通过测定甲功观察^131I治疗后早发甲减发生率及首次甲亢治愈率.结果 ^131I治疗后3月、6月、12月甲减的发生率及首次甲亢的治愈率A组分别为8.72％、12.33％、20.28％、81.16％;B组分别为4.29％、5.49％、7.69％、76.92％;C组分别为4.37％、5.02％、7.04％、61.97％.结论 小剂量的优甲乐能降低^131I治疗后早发甲减的发生率,同时甲亢的治愈率又不下降.

Observation of Euthyrox Intervention on Early Hypothyroidism of Patients with Hyperthyrosis After ^131I Treatment

Objective To explore the impact of interference through different does of Euthyrox （L-T4） on the early hypothyroidism of patients with hyperthyroid after ^131I treatment.Methods 218 patients with Graves＇disease were divided into 3 random groups.Group A contained 69 patients only treated by ^131I and severed as control group; Group B had 78 samples which gave L-T4 25 μg/d for the next successive 20 days after 21 day of ^131I treatment.Group C had 71 samples which gave L-T4 100 μ g/d for the next successive 20 days after 21day of ^131I treatment.The early hypothyroidism rate and the cure rate of hyperthyrosis were observed by measurement of thyroid function.Results The early hypothyroidism rate and the cure rate of hyperthyrosis of group A after 3,6,12 months treated by ^131I were 8.72%,12.33%,20.28% and 81.16% respectively.GroupB were 4.29%,5.49%,7.69% and 76.92%.Group C were 4.37%,5.02%,7.04% and 61.97%.Conclusion Small does of Euthyrox could reduce the early hypothyroidism rate in patients with hyperthyrosis after ^131I treatment I and would not reduce the cure rate of hyperthyrosis.