反射波增强指数与动脉硬化指标相关性的研究

目的 探讨反射波增强指数（AI）与肱-踝动脉脉搏波传导速度（baPWV）之间的相关性及其影响因素.方法 选择2010年4-6月北京市石景山区首钢地区参与调查研究的社区居民1 752例,年龄23～90岁,平均（59.82＆#177;11.88）岁.应用科林HEM-9000AI检测仪测量AI,科林无刨动脉硬化测定仪VP-1000测量baPWV及踝臂指数（ABI）,彩色多普勒超声仪采集双侧颈动脉图像,测量双侧颈动脉内-中膜厚度（IMT）.结果 ABI≤0.9组与ABI＞0.9组、IMT≥0.9 mm组与IMT＜ 0.9 mm组比较,baPWV差异均有统计学意义（P＜0.05）,而AI75（心率为75次/min时的标准校正值）的组间差异无统计学意义.AI与baPWV低度相关（r=-0.068,P=0.005）；多因素回归分析显示,性别、年龄、体质指数、腰臀比、心率、ABI和收缩压是AI的相关因素.结论 AI的相关影响因素较多,且与baPWV的相关性较差,不能单独作为评价动脉僵硬度的敏感、可靠指标.

The association between augmentation index and arterial stiffness index

Objective To explore the association between arterial system augmentation index（AI） and brachial-an- kle pulse wave velocity （baPWV）. Methods All subjects were selected from a local comnmnity. The study included l 752 people living in Shijingshan district, Beijing during April to June,2010. Subjects whose age ranged from 23 to 90 years old （59.82±11.88） years old] were included and 56.7% of the subjects were women. Pulse wave at the left radial artery. was measured and the AI was calculated by Colin pulse wave detection device HEM9000AI. baPWV and ankle-brachial index （ABI） were measured using Colin noninvasive arteriosclerosis tester VP-IO00. Color doppler flow imaging was used to measure intima-media thickness （IMT） of the bilateral carotid artery. Results The baPWV was significantly higher in ABI≤0.9 group and IMT≥0.9 mm group, while there was no significant difference of AITs between groups. AI had a low correlation with baPWV （r = -0.068, P = 0.005）. Partial correlation analysis showed that there was no significant association between AI and baPWV （r = -0.033, P = 0.17）. In multiple stepwise regression analysis, the factors of AI included gender, age, BMI, waist-to-hip ratio, heart rate, ABI and systolic pressure. Conclusion No significant correlation can be found between AI and baPWV. Various factors may influence the measurement of AI. This study suggests that AI may not be a sensitive and reliable index for the evaluation of arterial stiffness.