男性性激素结合球蛋白与胰岛素抵抗的关系

目的 研究男性血清性激素结合球蛋白（SHBG）与胰岛素抵抗（IR）的关系.方法 用随机方法以70名健康男性为对照组,另外抽取30例血糖正常、胰岛素浓度增高为IR组,30例血糖、胰岛素浓度均增高为糖尿病组,年龄均在30 ～ 50岁之间,采用化学发光法测定血清SHBG水平.分别比较三组血清SHBG水平,分析SHBG与IR的相关性.结果 胰岛素抵抗组、糖尿病组血清SHBG水平相较对照组显著降低,差异有统计学意义（P＜0.05）.从实验数据的相关性分析发现,对照组血清SHBG浓度与胰岛素浓度（r=-0.46,P＜0.05）呈负相关,差异有统计学意义（P＜0.05）;而胰岛素抵抗组相较糖尿病组血清胰岛素浓度改变时,SHBG浓度改变差异无统计学意义（P＞0.05）.结论 男性血清SHBG与IR有一定的相关性,低血清SHBG水平可以认为是IR以及糖尿病发生的一个危险因子,有助于IR以及糖尿病的诊断及排除.

Relationship Between Sex Hormone-binding Globulin and Insulin Resistance in Man

Objective To explore the relationship between sex hormone-binding globulin and insulin resistance in man.Methods 70 normal people were selected as reference group,30 people with higher insulin as insulin resistance group,and 30 people with both higher globulin and higher insulin as diabetes group.The serum SHBG levels in all groups were determined by CLIA.Results The serum SHBG levels in insulin resistance group and diabetes group were decreases incredibly compared with control group （P ＜ 0.05）.The serum SHBG levels in control group was negatively correlated with insulin level （r =-3.46,P ＜ 0.05）.The serum SHBG levels in insulin resistance group and diabetes group did not regularly change as the growing of insulin concentration.Conclusion The serum SHBG in man is related with insulin levels.The lower serum SHBG level might be regarded as the risk signal of insulin resistance and diabetes,and help to diagnosis of these two diseases.