Peculiarities of active avoidance conditioning in rats with various forms of inherited arterial hypertension |
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Authors: | L. V. Loskutova A. V. Filatov N. I. Dubrovia A. L. Markel’ |
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Affiliation: | (1) Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Russia;(2) Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk |
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Abstract: | Peculiarities of active avoidance conditioning were studied in NISAG rats (hereditary stress-induced arterial hypertension) and spontaneously hypertensive SHR rats. Conditioning was successful in 90% normotensive Wistar rats and in only 9.1% NISAG rats. Hypertensive SHR rats were intermediate between Wistar and NISAG rats by their learning capacity (66.7%). Our results suggest that differences in learning capacity of hypertensive rats are determined by genetic characteristics of animal behavior and emotional state, rather than blood pressure elevation. __________ Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 10, pp. 386–388, October, 2006 |
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Keywords: | arterial hypertension memory conditioned active avoidance response |
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