奥扎格雷抗血小板聚集作用的临床观察

目的比较奥扎格雷与阿司匹林对血小板聚集作用的影响,分析二者抵抗概率。方法脑梗死患者120例,随机分为奥扎格雷组与阿司匹林组(各60例),分别用二磷酸腺苷(ADP)、花生四烯酸(AA)诱导,进行血小板聚集试验,检测最大血小板聚集率(MAR)。各组患者均于入院当天、治疗第14天检测血小板聚集率。结果奥扎格雷组与阿司匹林组血小板聚集功能在同一诱导剂作用下,差异无统计学意义,都存在抵抗、半抵抗现象。结论奥扎格雷、阿司匹林对血小板聚集率影响的差异无统计学意义,均可作为抗血小板聚集药物,但也存在抵抗现象。奥扎格雷抗血小板聚集的长期临床效果、与其他抗血小板聚集药物联合应用能否解决抵抗问题,还需进一步的大规模临床实验研究。

Effect of ozagrel on anti-platelet aggregation

Objective To observe the effects of ozagrel and aspirin on platelet aggregation and analyze the resistance probability.Methods 120 patients with cerebral infarction were divided randomly into ozagrel group and aspirin group(60 cases in each group),and they were induced by adenosine dophosphact(ADP)and arachidonic acid(AA)respectively.The largest platelet aggregation(MAR)was detected.The platelet aggregation was tested on the first and 14 th day of hospitalization.Results There was no significant difference ...