| 依达拉奉对急性脑梗死患者血清NSE、hs-CRP的影响 |
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| 引用本文： | 陈林芳,丁新生,田向阳,赵卫东.依达拉奉对急性脑梗死患者血清NSE、hs-CRP的影响[J].实用药物与临床,2011,14(5). |
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| 作者姓名： | 陈林芳 丁新生 田向阳 赵卫东 |
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| 作者单位： | 1. 南京医科大学附属淮安第一医院,南京,223300
2. 南京医科大学附属第一医院神经内科,南京,210000 |
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| 摘 要： | 目的研究急性脑梗死患者血清中神经元特异性烯醇化酶(NSE)、超敏C反应蛋白(hs-CRP)含量变化与神经功能缺损的关系及依达拉奉对急性脑梗死的影响。方法选择急性脑梗死患者90例,随机分为对照组(常规治疗)和依达拉奉组(依达拉奉+常规治疗,依达拉奉30 mg+0.9%氯化钠溶液100 mL,静脉滴注,2次/d,连续14 d),检测治疗前、治疗后7 d和14 d患者血清中NSE、hs-CRP和神经功能缺损的变化。结果急性脑梗死组患者血清神经元特异性烯醇酶、超敏C反应蛋白含量与神经功能缺损评分呈明显正相关(P<0.01)。治疗后,依达拉奉组患者血清NSE、hs-CRP水平降低,与对照组比较,差异均有统计学意义(P<0.05)。治疗后依达拉奉组的神经功能缺损评分明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论急性脑梗死患者血清中NSE、hs-CRP含量升高,其含量可反映脑梗死的病情程度,可以作为脑梗死患者脑损害程度的客观指标。依达拉奉可以降低NSE和hs-CRP水平,能有效改善急性脑梗死的脑损害程度。
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| 关 键 词： | 急性脑梗死 神经元特异性烯醇化酶 超敏C反应蛋白 神经功能缺损 依达拉奉 |
Effect of edaravone on serum neuron-specific enolase (NSE) and high-sensitivity Creactive protein (hs-CRP) levels of patients with acute cerebral infarction |
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| CHEN Lin-fang,DING Xin-sheng,TIAN Xiang-yang,ZHAO Wei-dong.Effect of edaravone on serum neuron-specific enolase (NSE) and high-sensitivity Creactive protein (hs-CRP) levels of patients with acute cerebral infarction[J].Practical Pharmacy and Clinical Remedies,2011,14(5). |
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| Authors: | CHEN Lin-fang DING Xin-sheng TIAN Xiang-yang ZHAO Wei-dong |
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| Institution: | CHEN Lin-fang1,DING Xin-sheng2*,TIAN Xiang-yang1,ZHAO Wei-dong1(1.Huai'an First Hospital of Nanjing Medical University,Nanjing 223300,China,2.The First Hospital of Nanjing Medical University,Nanjing 210000,China) |
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| Abstract: | Objective To investigate the changes of serum neuron-specific enolase(NSE),high-sensitivity Creactive protein(hs-CRP) levels and the relationship of NSE,hs-CRP levels w ith neurological function defect in acute cerebral infarction patients,and the influence of edaravone on it.Methods 90 patients w ith acute cerebral infarction w ere randomly divided into control group and edaravone group,the control group w ere given routine treatment,apart from routine therapy,the edaravone group w ere added edaravone 30 m... |
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| Keywords: | Acute cerebral infarction Neuron-specific enolase High-sensitivity C-reactive protein Neurological function defect Edaravone |
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