| 美洛西林与四种常用输液的配伍稳定性考察 |
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| 引用本文： | 臧治满,李晨晨,谭爱萍. 美洛西林与四种常用输液的配伍稳定性考察[J]. 实用药物与临床, 2011, 14(5): 397-400 |
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| 作者姓名： | 臧治满 李晨晨 谭爱萍 |
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| 作者单位： | 1. 大连医科大学附属第一医院西药局,大连,116011
2. 大连医科大学药学院,大连,116044 |
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| 摘 要： | 目的考察注射用美洛西林钠在4种临床常用输液中的稳定性。方法按临床常用剂量配制美洛西林钠的0.9%氯化钠注射液、10%葡萄糖注射液、5%葡萄糖注射液以及5%葡萄糖+0.9%氯化钠注射液,考察上述4种配伍液于0、0.5、1、2、3、4、5、6 h的pH值、颜色和澄明度外观变化。用高效液相色谱法考察在上述时间点下,配伍液中美洛西林钠的含量变化。采用BDS-C18(250 mm×4.6 mm,5μm)色谱柱,以磷酸盐缓冲液(pH值为5.8)∶甲醇(60∶40)为流动相,检测波长:210 nm,柱温:30℃,进样量:1μL。结果以本实验所建立的色谱条件对美洛西林钠进行检测,专属性好,能达到基线分离,美洛西林钠的线性范围为1～12 mg/mL(r=0.9999),日内精密度RSD<2.0%,4种输液配伍液在6 h内峰面积均无明显变化,变异系数RSD均<2.0%。结论美洛西林钠与0.9%氯化钠注射液、10%葡萄糖注射液、5%葡萄糖注射液以及5%葡萄糖+0.9%氯化钠注射液配伍后稳定,临床上可配伍使用。
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| 关 键 词： | 美洛西林钠 配伍 稳定性 高效液相色谱法 |
Compatible stability of mezlocillin sodium for injection with four infusions |
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| ZANG Zhi-man,LI Chen-chen,TAN Ai-ping. Compatible stability of mezlocillin sodium for injection with four infusions[J]. Practical Pharmacy and Clinical Remedies, 2011, 14(5): 397-400 |
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| Authors: | ZANG Zhi-man LI Chen-chen TAN Ai-ping |
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| Affiliation: | ZANG Zhi-man1,LI Chen-chen2,TAN Ai-ping1(1.Department of Pharmacy,The First Hospital of Dalian Medical University,Dalian 116011,China,2.College of Pharmacy,Dalian Medical University,Dalian 116044,China) |
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| Abstract: | Objective To study the compatible stability of mezlocillin sodium for injection with four infusions.Methods According to the clinical common dose,the solution of mezlocillin sodium with 0.9% sodium chloride injection,5% dextrose injection,10% dextrose injection,5% dextrose +0.9% sodium chloride injection were prepared.The pH value,color,external appearance changes(color and clarity)and the content of mezlocillin sodium in the four compatibility solutions were determined at 0,0.5,1,2,3,4,5 and 6 h.The BDS-C1... |
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| Keywords: | Mezlocillin sodium Compatibility of medicine Stability HPLC |
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