| RP-HPLC考察注射用盐酸头孢吡肟与氟康唑氯化钠注射液配伍的稳定性 |
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| 引用本文： | 郑芳,钟基大,朱雪松,李春雷,李志浩. RP-HPLC考察注射用盐酸头孢吡肟与氟康唑氯化钠注射液配伍的稳定性[J]. 实用药物与临床, 2011, 14(5): 401-403 |
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| 作者姓名： | 郑芳 钟基大 朱雪松 李春雷 李志浩 |
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| 作者单位： | 1. 湖北医药学院附属东风医院药剂部,湖北,十堰,442008
2. 湖北医药学院附属东风医院感染科,湖北,十堰,442008 |
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| 摘 要： | 目的考察室温(20±1)℃下,注射用盐酸头孢吡肟与氟康唑氯化钠注射液配伍的稳定性。方法采用反相高效液相色谱法测定配伍液中头孢吡肟与氟康唑0～6 h内的含量变化,并观察配伍液的外观及pH值。结果注射用盐酸头孢吡肟与氟康唑氯化钠注射液6 h内配伍液外观、pH值及含量均无明显变化。结论在室温(20±1)℃下,注射用盐酸头孢吡肟与氟康唑氯化钠注射液配伍后6 h内可使用。
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| 关 键 词： | 头孢吡肟 氟康唑 高效液相色谱法 配伍 稳定性 |
Stability of cefepime sodium for injection mixed with fluconazole and sodium chloride injection by RP-HPLC |
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| ZHENG Fang,ZHONG Ji-da,ZHU Xue-song,LI Chun-lei,LI Zhi-hao. Stability of cefepime sodium for injection mixed with fluconazole and sodium chloride injection by RP-HPLC[J]. Practical Pharmacy and Clinical Remedies, 2011, 14(5): 401-403 |
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| Authors: | ZHENG Fang ZHONG Ji-da ZHU Xue-song LI Chun-lei LI Zhi-hao |
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| Affiliation: | ZHENG Fanga,ZHONG Ji-dab,ZHU Xue-songa,LI Chun-leia,LI Zhi-haoa(a.Department of Pharmacy,b.Department of Infection,Dongfeng General Hospital,Hubei University of Medicine,Shiyan 442008,China) |
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| Abstract: | Objective To study the stability of cefepime sodium for injection mixed with fluconazole and sodium chloride injection at room temperature[(20±1)℃].Methods Changes of the contents of cefepime sodium and fluconazole were determined by RP-HPLC,and the appearance,pH values were observed within 6 hours.Results There was no significant change in the contents,appearance and pH values of the compatible solution at room temperature[(20±1)℃]for 6 h.Conclusion The mixture of cefepime sodium for injection and fluconazole and sodium chloride injection can be used after storing for 6 h at room temperature[(20±1)℃]. |
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| Keywords: | Cefepime Fluconazole HPLC Compatibility Stability |
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