| 肾血管性高血压大鼠模型复制方法 |
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| 引用本文： | 黄国辉,冯建芳,石召锋,尹路,韩雪,姜静静,李静娟,李艳. 肾血管性高血压大鼠模型复制方法[J]. 河南科技大学学报(医学版), 2011, 29(4): 247-249 |
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| 作者姓名： | 黄国辉 冯建芳 石召锋 尹路 韩雪 姜静静 李静娟 李艳 |
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| 作者单位： | 河南科技大学医学院,河南洛阳,471003 |
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| 基金项目： | 河南科技大学大学生科研训练计划(SRTP)资助项目 |
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| 摘 要： | 目的介绍一种新的肾性高血压大鼠模型复制方法。方法采用大鼠背部开口行双侧肾动脉狭窄术复制肾性高血压模型。选用94只雄性Sprague-Dawley(SD)大鼠,随机分为2组。对照组(假手术组)20只行假手术;模型组74只经背部开口行双侧肾动脉狭窄术;术后6周测定成活率、成模率和血压。结果术后成活率87.2%、成模率79.7%,模型组收缩压(165±6)mmHg,两组血压有显著性差异(P<0.05)。结论经背部开口行大鼠双侧肾动脉狭窄术是一种简便安全的新方法。
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| 关 键 词： | 肾血管性高血压 动物模型 大鼠 双肾双夹 |
Model Rebuilding Method of Renovascular Hypertensive Rats |
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| HUANG Guo-hui,FENG Jian-fang,SHI Zhao-feng,et al. Model Rebuilding Method of Renovascular Hypertensive Rats[J]. Journal of Henan University of Science & Technology:Medical Science, 2011, 29(4): 247-249 |
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| Authors: | HUANG Guo-hui FENG Jian-fang SHI Zhao-feng et al |
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| Affiliation: | HUANG Guo-hui,FENG Jian-fang,SHI Zhao-feng,et al (Medical College,Henan University of Science and Technology,Luoyang 471003,China) |
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| Abstract: | Objective To introduce a new method of producing renovascular hypertensive model in rats. Methods To produce renovascular hypertensive model by performing two-kidney two-clip method with new titanium alloy clips via back bi-incising in rats.94 male SD rats were randomly divided into two groups.In control group(sham group),20 rats were carried out by sham operation.In experimental group,both renal arteries of 74 rats were occluded by clips from back bi-incising.After 6 weeks,the survival rate,the model rate ... |
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| Keywords: | renovascular hypertensive animal model rats two-kidney two-clip |
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