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米诺环素对戊四氮致疒间大鼠海马神经元凋亡的保护作用
引用本文:王克玲,郑华城,刘建荣,施荣富,董天津. 米诺环素对戊四氮致疒间大鼠海马神经元凋亡的保护作用[J]. 脑与神经疾病杂志, 2011, 19(5): 334-337
作者姓名:王克玲  郑华城  刘建荣  施荣富  董天津
作者单位:河北省儿童医院神经内科,石家庄,050031
基金项目:河北省科学技术研究与发展指导项目(07276106)
摘    要:目的探讨米诺环素对神经元凋亡的保护作用及与剂量的关系。方法采用戊四氮(PTZ)建立的癫疒间大鼠模型,用灌胃法给不同剂量的米诺环素后麻醉大鼠,灌注取脑进行石蜡切片制备及免疫组化检测,采用HPIAS-1000高清晰度彩色病理图文分析系统进行图像分析,观察大鼠海马区细胞凋亡变化。结果对照组与PTZ组比较,对照组凋亡数目少(P<0.05);MT1组与PTZ组比较,细胞凋亡无差异(P﹥0.05);MT2组与PTZ组比较,MT2组细胞凋亡数少(P<0.05);MT3组与PTZ组比较,MT3组细胞凋亡多(P<0.05)。各干预组之间比较,MT2组细胞凋亡较MT3组、MT1组都少(P<0.05)。结论米诺环素在适当的浓度范围内有神经元保护作用。

关 键 词:米诺环素  海马神经元  细胞凋亡

Protection of Minocycline against apoptosis of hippocampal neurons of epileptic rats induced by Bentylenetetrazol(PTZ)
WANG Ke-ling,ZHENG Hua-cheng,LIU Jian-rong,SHI Rong-fu,DONG Tian-jin. Protection of Minocycline against apoptosis of hippocampal neurons of epileptic rats induced by Bentylenetetrazol(PTZ)[J]. Journal of Brain and Nervous Diseases, 2011, 19(5): 334-337
Authors:WANG Ke-ling  ZHENG Hua-cheng  LIU Jian-rong  SHI Rong-fu  DONG Tian-jin
Affiliation:WANG Ke-ling,ZHENG Hua-cheng,LIU Jian-rong,SHI Rong-fu,DONG Tian-jin,Department of Neurology,the Children Hospital of Hebei Province,Shijiazhuang 050031,China
Abstract:Objective To explore the protective effects of minocycline against apoptosis of hippocampal neurons and the relationships between doses.Methods Treated epileptic rats induced by pentylenetetrazol(PTZ) with different doses of minocycline using gavage method,the brain perfusion preparaed for paraffin sections and immunohistochemistry,the changes of apoptosis in rat hippocampus were observed by image analysis of HPIAS-1000 high-resolution color graphic analysis system pathology image analysis.Results Compared ...
Keywords:Minocycline  Hippocampal neurons  Aapoptosis  
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