| 增殖细胞核抗原在大肠癌中的表达及其临床意义 |
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| 引用本文： | 苏文利,杨国樑,熊斌. 增殖细胞核抗原在大肠癌中的表达及其临床意义[J]. 中国肿瘤临床与康复, 2004, 11(6): 501-502 |
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| 作者姓名： | 苏文利 杨国樑 熊斌 |
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| 作者单位： | 1. 上海中医药大学普陀临床医学院普外科,200062
2. 武汉大学中南医院肿瘤科,430071 |
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| 摘 要： | 目的 研究大肠癌中增殖细胞核抗原 (PCNA)的表达及其临床意义。方法 应用免疫组化S P法对 5 4例大肠癌组织、相应大肠黏膜及 14例转移淋巴结中PCNA的表达进行检测。结果 大肠癌组织中PCNA强表达阳性率为 37.0 % ,转移淋巴结组织中PCNA强表达阳性率为 78.6 % (P <0 .0 5 )。有淋巴结转移的大肠癌组织中PCNA的强表达阳性率为 5 0 .0 % ,无淋巴结转移的大肠癌中PCNA强表达阳性率为 32 .5 % (P >0 .0 5 )。结论 PCNA的高表达在大肠癌的发生发展和转移过程中起着重要作用。
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| 关 键 词： | 结直肠肿瘤 增殖细胞核抗原 免疫组化 |
| 文章编号： | 1005-8664(2004)06-0501-02 |
| 修稿时间： | 2003-12-19 |
Expression of PCNA in colorectal carcinoma and its clinical significance |
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| SU Wen-Li,YANG Guo-Liang,XIONG Bin. Expression of PCNA in colorectal carcinoma and its clinical significance[J]. Chinese Journal of Clinical Oncology and Rehabilitation, 2004, 11(6): 501-502 |
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| Authors: | SU Wen-Li YANG Guo-Liang XIONG Bin |
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| Abstract: | Objective To study the expression of proliferative cell nuclear antigen(PCNA) and its clinical signiflcance in colorectal carcinoma.Methods The expression of PCNA was examined by immunohistochemical S-P methods in 54 colorectal carcinoma tissues and 14 lymph nodes with metastases.Results The positive rate of PCNA was 37.0% in colorectal carcinoma,and was 78.6% in lymph nodes with metastases (P<0.05). The positive rate of PCNA was 50.0% in colorectal carcinoma tissues with lymph node metastasis,and was 32.5% in those without metastasis(P>0.05).Conclusion The expression of PCNA may play a role in the development and matastasis of colorectal carcinoma. |
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| Keywords: | Colorectal neoplasms PCNA Immunohistochemistry $$$$ |
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