Ⅱ型糖尿病患者肺功能改变及相关因素分析

目的:本研究通过测定Ⅱ型糖尿病患者肺损害的有关指标,以进一步了解糖尿病患者肺损害的情况,并对相关因素进行分析,以加深对糖尿病的进一步认识。方法:病例组为20例Ⅱ型糖尿病,另选择20例无糖尿病、呼吸道疾病史及不吸烟的健康人作为对照组。两组间年龄、性别、体重均较匹配。并同时测定动脉血血气分析,PH值、动脉血氧分压(PaO2)、动脉血CO2分压(PaCO2)。测定血压、空腹血糖(FBG)、早餐后2h血糖(PBG)、HbA1C、甘油三脂(TG)、胆固醇(TC)、尿微量白蛋白(UAER)等,并对其作相关分析。结果:糖尿病组PaO2显著低于对照组(P<0.05)、PaCO2显著高于对照组(P<0.05)。多因素线形回归分析表明,糖尿病肺损害与糖尿病的血压、空腹血糖(FBG)、早餐后2h血糖(PBG)、HbA1C、甘油三脂(TG)、胆固醇(TC)、尿微量白蛋白(UAER)等明显相关。结论:Ⅱ型糖尿病患者既存在限制性、阻塞性和混合性通气功能障碍,又存在着弥散性功能障碍,其发生与糖尿病患者的血压、空腹血糖(FBG)、早餐后2h血糖(PBG)、HbA1C、甘油三脂(TG)、胆固醇(TC)、尿微量白蛋白(UAER)等明显相关。可能与糖尿病患者的肺间质纤维化和微血管病变有关。

Study the Changes and Correlation Factors of Pulmonary Functions in Patients with Type-2 Diabetes

Objective:To comprehend the lungs damaged circumstances and go further step and analyze the correlation factors through testing the related index of lungs damaged, to get deeer understanding the diabetes further. Method: 20 type-2 diabetes were selected into study. 20 nondiabetetes controls removing chronic respiratory disease and nonsmoking. Age,sex and weight were mated in two groups. To test arterial vigor analyzing PH value, arterial partial pressure of oxygen(PaO_2), arterial partial pressure of carbon dioxide(PaCO_2) the same time . To determine blood pressure,blood glucose before breakfast(FBG), blood glucose past breakfas(PBG), HbAlc,triglyceride(TG),cholesterol(TC),urine trace albumen excrete rate(UAER) et al,and make relevance analyzing.Result:PaO_2 was lower and PaCO_2 was higher in diabetes than in nondiabetes(P<0.05). Many-faceted round analyze indicate: the lungs damaging were related to blood pressure, FBG,PGB,HbA1c,TG,TC,UAER and so on clearly. Conclusion: The patients of the Type-2 diabetes exist restrictiveness,traffic jam and mixed ventilation function obstacle,exsist disperseness function obstale also. The occurence are related to their blood pressure,FBG, PBG, HbA1c,TG,TC UAER and so on clearly. The occurence are related to interstitial pulmonary fibrosis and blood capillary pathology probably.