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MDM2和p53共同染色可成为膀胱癌独立的预后指标
引用本文:高江平,王悦增,叶林阳,肖序仁,王晓雄,李炎唐. MDM2和p53共同染色可成为膀胱癌独立的预后指标[J]. 军医进修学院学报, 2001, 22(1): 11-13
作者姓名:高江平  王悦增  叶林阳  肖序仁  王晓雄  李炎唐
作者单位:1. 解放军总医院泌尿外科,
2. 白求恩医科大学病理学教研室,
摘    要:目的:以免疫组织化学染色的方法,研究 MDM2 和 p53 蛋白在膀胱癌中的表达,以及与病理和临床表现之间的关系。方法:应用抗 MDM2 和 p53 的单克隆抗体,以标准的 LSAB 方法,共分析了 131 例组织学确诊的膀胱癌标本。结果:MDM2染色阳性的肿瘤为 39 例(29.8%),阴性的肿瘤为 92 例(70.2%)。MDM2 染色在不同细胞分级和不同临床分期之间无统计学差异,对是否复发及生存率也无影响。p53 染色阳性的肿瘤为 86 例(65.6%),G3级阳性的比例(84.1%)明显高于 G1-2 级(56.3%,P=0.0012);浸润型(T2-4)肿瘤阳性的比例(75.8%)明显高于表浅型(Ta-1)肿瘤(55.4%,P<0.001)。p53 阳性患者的生存率明显低于阴性患者(P=0.007)。两种蛋白表达之间无明显关系。P53+/MDM2-的患者生存率最低,且在多因素分析中,成为独立的预后因素(P=0.0046)。结论:P53+/MDM2-患者的生存率最低,并且是独立的预后因素。MDM2和p53共同染色,可为预后判断提供更准确的资料。

关 键 词:膀胱癌 免疫组化染色 MDM2 p53 预后

MDM2 and p53stain simultaneously has independent prognostic significance in human bladder cancer
GAO Jiang-ping,WANG Yao-zeng,YE Lin-yang,XIAO Xu-ren,WANG Xiao-xiong,LI Yan-tang. MDM2 and p53stain simultaneously has independent prognostic significance in human bladder cancer[J]. Academic Journal of Pla Postgraduate Medical School, 2001, 22(1): 11-13
Authors:GAO Jiang-ping  WANG Yao-zeng  YE Lin-yang  XIAO Xu-ren  WANG Xiao-xiong  LI Yan-tang
Abstract:Objective:To detect the prognostic value of the expression of MDM2 and p53 protein, as well as the relationship of these two proteins as determined by immunohistochemistry in bladder cancer. Methods: Bladder tumor samples from 131 patients were assessed immunohistochemically using the specific monoclonal antibody and labeled streptavidin biotin staining against MDM2 and p53 protein. Results:MDM2 and p53 positive stains were 39 cases (29.8%) and 87 cases (65.6%), respectively There was no significant correlation of MDM2 staining with the histological grade, clinical stage and prognoses p53 accumulation were significantly correlated with high histologic grade (P=0.0012), high clinical stage (P<0.0001) and reduced survival (P=0.007) No relationship was observed between MDM2 and p53 in staining status or intensity. The lowest survival rate was seen in p53+/MDM2, pattern Multivariate analysis demonstrated that p53+/MDM2 has significant statistical correlation with unfavorable outcome (P=0.0046) Conclusion:p53+/MDM2 pattern is independent prognostic impact for tumor progression in bladder cancer. The simultaneous immunostaining for MDM2 and p53 could be important prognostic factor in patients affected by bladder cancer.
Keywords:bladder cancer  immunohistochemistry  MDM2  p53
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