结节病患者肺功能变化研究

目的：肺结节病患者肺功能测试的研究。方法：40例肺结节病患者不同时期肺功能测试结果和应用激素的回顾分析。结果：显示此类患者有限性通气功能障碍并伴有弥散功能下降和小气道功能受限，PaO2明显下降,pH升高，PaCO2也有下降的趋势。激素治疗结果显示，患者的MMF有明显的提高。其它肺功能指标如VC，RV，RV/TLC，MVV，FEV1，DLCO等都有升高的趋势。结论：VC，RV，MMF，DLCO，DLCO/VA等对诊断结节病的病情发展有直接参考价值，而MMF在糖皮质激素治疗后有显著的变化，提高MMF对结节病的治疗和预后具有动态参考价值。

The study of lung function tests in thoracic sarcoidosis patients

Objective:This article reported the study of lung function tests in thoracic sarcoidosis patients Methods:Retrospectively analyzing the results of lung function tests in different periods and the effects of glucocorticoid in 40 thoracic sarcoidosis patients Results:The results showed that these patients had restrictive ventilating obstacles with decreased DLCO and deterioration of small airway function parameters There were obvious decreasing in PaO 2 and increasing in ph,and PaCO 2 also revealed the decreasing tendency The curative results with dehydrocortisone demonstrated that MMF had largely improved in these thoracic sarcoidosis patients,and other lung function parameters,such as VC, RV, RV/TLC, MVV, FEV 1 , DLCO, also showed the tendencies of turning better Conclusion:We concluded that VC, RV, MMF, DLCO, DLCO/VA had the values of evaluating the progress of thoracic sarcoidosis,and there was a good value for MMF in evaluating the effects of glucocorticoid for thoracic sarcoidosis patients