| Effect of transfected angiotensin Ⅱreceptor anti—sense nucleotide on the growth of cardiomyocytes in vitro |
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| 作者姓名： | 杨永健 祝善俊 祝之明 胡厚祥 丁刚 |
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| 作者单位： | YANGYong-jian，ZHUShan-jun，ZHUZhi-ming，HUHou-xiang，DING Gang Department of Cardiology，Xinqiao Hospital，Third Military Medical University，Chongqing400037，China 2 Center of Hypertensive Diseases，Daping Hospital，Third Military Medical University，Cho |
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| 基金项目： | Supported by National Natural Science Foundation of China(No.39770314，39725013) |
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| 摘 要： | AsakeymoleculeinRenin-Angiotensin-System(RAS),AngiotensinⅡ(AngⅡ)playsanimportantroleinthepathogenesisofcongestiveheartfailurethroughitseffectoninducingcardiacmyocytehyper-trophyandmatrixfibrosisafteritiscombinedwithitsspecificreceptor(AT1)［1,2］.Regressionofthecardiomy-ocytichypertrophyhasbecomeanimportantproblemtostudy.Inthiswork,weconstructedaplasmidPAT1Acontaininganti-sensenucleotide,andtransfectedcar-diomyocyteswiththeplasmidtoobserveitsinfluenceonthecellgrowthinordertoacquiremorei…
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| 关 键 词： | 血管紧张肽Ⅱ受体 反义核苷酸 心肌细胞生长 先天性心脏病 |
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