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Effect of glial cell line-derived neurotrophic factor on peripheral nerve regeneration in adult rat |
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| Authors: | CHEN Zhe-yu LI Jian-hong ZHENG Xing-dong LU Chang-lin HE Cheng |
| Institution: | Department of Neurobiology, Department of Basic Medicine, Second Military Medical University, Shanghai 200433,China Department of Neurobiology, Department of Basic Medicine, Second Military Medical University, Shanghai 200433,China Department of Neurobiology, Department of Basic Medicine, Second Military Medical University, Shanghai 200433,China Department of Neurobiology, Department of Basic Medicine, Second Military Medical University, Shanghai 200433,China Department of Neurobiology, Department of Basic Medicine, Second Military Medical University, Shanghai 200433,China |
| Abstract: | Objective:To studytheeffectof glialcellline-derivedneurotrophic(GDNF)on adultperipheralnerve regeneration.Methods:Transectionedsciaticnerveinadultratswassuturedintosiliconechannel.GDNFor SALsolution wasinjectedintothesiliconechannelsduringoperation.Fourweekslater,theeffectof GDNFon axonalregenerationwas evaluatedby degenerativeneurofiberstainingandHRPretrogradetracing.Results:ComparedwithSAL group,the percentageof degenerativeneurofiberareasdecreasedfrom17.3%to1.9%(P<0.01)andtheratioof labeledspinalsomas numberwassignificantlyincreasedfrom43.5%to68.3%(P<0.01)inGDNFgroup.Conclusion:Theresultssuggestthat exogenousGDNFcanobviouslyenhanceadultperipheralnerveregeneration. |
| Keywords: | glial cell line-derived neurotrophic factor sciatic nerve nerve regeneration |
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