| ^32P局部照射预防猪冠状动脉再狭窄研究 |
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| 引用本文： | 文应峰,盖鲁粤,张端珍,曾永寿.^32P局部照射预防猪冠状动脉再狭窄研究[J].军医进修学院学报,2001,22(2):97-98. |
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| 作者姓名： | 文应峰 盖鲁粤 张端珍 曾永寿 |
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| 作者单位： | 1. 解放军总医院心内科,
2. 楚雄州人民医院, |
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| 摘 要： | 目的：评价^32P灌注球囊预防再狭窄的有效性、可行性和安全性。方法：对猪冠状动脉左前降支行过度球囊扩张术后，治疗组以^32P作血管内照射，对照组作假照射。术后35d收获目标血管、检测血管形态、细胞增殖百分比等。结果：治疗组血管腔面积较对照组明显增大（P＜0．01），新生内膜面积、血管狭窄程度和各层PCNA阳性细胞明显减小（P均＜0．01）。结论：^31P灌注球囊照射预防冠状动脉再狭窄有效、安全而且可行。
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| 关 键 词： | 冠状动脉疾病 血管成形术 放射治疗 ^32P 猪 |
Prevention of coronary artery restenosis by local ~ (32) phosphate irradiation in swine |
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| WEN Ying feng,GAI Lu yue,ZHANG Duan zhen,ZHENG Yong shou.Prevention of coronary artery restenosis by local ~ (32) phosphate irradiation in swine[J].Academic Journal of Pla Postgraduate Medical School,2001,22(2):97-98. |
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| Authors: | WEN Ying feng GAI Lu yue ZHANG Duan zhen ZHENG Yong shou |
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| Abstract: | Objective:To evaluate efficacy,feasibility and safety of 32 P liquid filled balloon irradiation in preventing restenosis in swine.Methods:After overstretch balloon angioplasty injury,the left anterior descending branch(LAD) of coronary artery was treated with 32 P or control 35 days later ,the morphometry and histopathologic analyses were carried out in the injured segments.Results:The lumen area was significantly larger ( P <0 01) while the neointima area( P <0 01),percent area stenosis ( P <0 01) and PCNA positive cells ( P <0 01) reduced sighificantly in the radiotherapeutic animals than in the control animals. Conclusion:The approach was safe,effective and feasible in preventing restenosis. |
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| Keywords: | coronary disease angioplasty radiotherapy |
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