| Study on the correlation between CT appearance and expression of p53 protein in peripheral lung cancer |
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| 引用本文： | 陈江浩,黄学胜,刘锟,杨宁. Study on the correlation between CT appearance and expression of p53 protein in peripheral lung cancer[J]. 中国人民解放军军医大学学报, 2001, 0(3) |
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| 作者姓名： | 陈江浩 黄学胜 刘锟 杨宁 |
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| 作者单位： | CHENJiang-hao，HUANGXue-sheng，LIUKun，YANGNing Department of Vascular Surgery，Xijing Hospital，Fourth Military Medical University，Xi'an710032，China 2 Department of Thoracic Surgery，91Hospital，Gunzhou272013，China 3 Department of Thoracic Sur |
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| 摘 要： | p53isanimportanttumorsuppressorgene,itplaysacentralroleinthecontrolofcellproliferationandcarcinogenesis.p53mutationscanstimulateun-controlledcellgrowthanddivisionwhichcontributetothedevelopmentofvarioustumors[1－6].Recently,studiesontherelationshipofCTappearancewithpathologiccharacteristicsinperipherallungcancerhavebeendeveloppingrapidly.Itisconceivablethattheproliferativestatesofthetumorscontributetotheirradiologicfeatures[7－12].Therefore,itisvaluabletoe-valuatethecorrelationbetweenCTappear…
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Study on the correlation between CT appearance and expression of p53 protein in peripheral lung cancer |
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| CHEN Jiang-hao HUANG Xue-sheng LIU Kun YANG Ning. Study on the correlation between CT appearance and expression of p53 protein in peripheral lung cancer[J]. Journal of Medical Colleges of PLA(China), 2001, 0(3) |
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| Authors: | CHEN Jiang-hao HUANG Xue-sheng LIU Kun YANG Ning |
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| Affiliation: | Department of Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China Department of Thoracic Surgery, 91 Hospital, Gunzhou 272013, China Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710032, China Department of Pathology, Faculty of Preclinical Medicine, Fourth Military Medical University, Xi'an 710032, China |
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| Abstract: | Objective: To investigate the correlation between CT appearance and expression of p53 protein in peripheral lung cancer. Methods: The expression of p53 protein was examined by means of SP immunohistochemical technique in 32 cases of peripheral lung cancer. Their correlation with the preoperative CT appearance was analyzed retrospectively.Results: The expression of p53 protein was correlated with tumor size, lobulation, cavitation, pleural indentation and mediastinal lymph node enlargement, but not with spiculation. Tumor with maximum diameter greater than 3 cm or with the presence oflobulation, cavitation, pleural indentation or mediastinal lymph node larger than 10 mm in short axis had a relatively higher level of p53 expression. Conclusion: CT signs of peripheral lung cancers are valuable not only in differentiating cancers from benign lesions, as known before, but also in providing further information for the malignant potential of cancers. Larger tumor size, lobulation, cavitation, pleural indentation, and mediastinal lymph node enlargement may be likely related to a higher degree of malignant potential and more aggressive tumor behavior. |
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| Keywords: | computed tomography lung neoplasms p53 protein malignant potential cell proliferation immunohisto chemistry |
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