| Elafin在气道炎症性疾病中的作用 |
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| 引用本文： | 邓玥,张婷,周向东.Elafin在气道炎症性疾病中的作用[J].国际呼吸杂志,2014,34(20):1576-1579. |
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| 作者姓名： | 邓玥 张婷 周向东 |
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| 作者单位： | 400010,重庆医科大学附属第二医院呼吸内科 |
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| 摘 要： | Elafin是一种内源性的低分子量丝氨酸蛋白酶抑制剂,它来自于其前体trappin-2（或称pre-Elafin）的蛋白水解.Elafin的N端区段可以在转谷酰胺酶的介导下与细胞外基质铰连,而C端可以继续发挥抗蛋白酶作用.此外,Elafin还有抗感染、抗炎和免疫调节作用.因此,在气道炎症性疾病的治疗方面,Elafin是一种极具吸引力的候选分子.
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| 关 键 词： | Elafin 气道炎症 治疗 |
Functions of Elafin in airway inflammatory disease |
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| Deng Yue,Zhang Ting,Zhou Xiangdong.Functions of Elafin in airway inflammatory disease[J].International Journal of Respiration,2014,34(20):1576-1579. |
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| Authors: | Deng Yue Zhang Ting Zhou Xiangdong |
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| Institution: | (Department of Respiratory Medicine, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China) |
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| Abstract: | Elafin is an endogeneous low molecular weight inhibitor of serine proteases.It is derived from a precursor,trappin-2 or pre-Elafin by proteolysis.Elafin has a unique N-terminal domain that enables it to become cross-linked to extracellular matrix proteins by transglutaminase,while retaining its inhibitory activity.Elafin has many biological functions as diverse as anti-bacterial,anti-fungal,anti-viral,anti-inflammatory,and immuno-modulatory functions,in addition to its inhibitory activity.Hence,Elafin has become an attractive candidate as therapeutic molecule in inflammatory lung disease. |
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| Keywords: | Elafin Arway inflammation Therapy |
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