输血相关性急性肺损伤研究进展

输血相关性急性肺损伤（transfusion-related acute lung injury,TRALI）是输血相关性疾病中最常见的类型.其发病率及病死率高,定义基于临床和影像学参数.TRALI分为免疫介导性和非免疫介导性,患者基础情况和输血因素共同决定着TRALI的发生.TRALI的预防主要包括避免使用女性供血者血浆制品及避免输注多个供血者的混合血浆.但目前所有预防措施只能减少而不是消除TRALI的发生,且对于这种危及生命的综合征尚无明确治疗方法,因此防治TRALI的工作任重而道远.本文对TRALI的定义、发病率、发病机制、临床表现、预防及治疗作一综述.

Research progress of transfusion-related acute lung injury

Transfusion-related acute lung injury （TRALI） is the common type of transfusionrelated disease.The incidence and mortality rate of TRALI are high,it is defined on the basis of clinical and radiographic parameters.TRALI is divided into immune mediated TRALI and non immune mediated TRALI.Patients and blood transfusion factors determine the occurrence of TRALI together.TRALI prevention mainly includes avoiding female blood donors and infusion of multiple donors.At present all preventive measures can only reduce the occurrence of TRALI,but not eliminate it.And there is no clear method for treatment of the life-threatening syndrome.So there is a long way to go for prevention and management of TRALI.In this paper,the definition,incidence,pathogenesis,clinical manifestation,prevention,and treatment of TRALI are reviewed.