30例胃间质瘤临床病理分析

目的：探讨胃间质瘤（GST）的免疫组化分型、临床病理特点。方法：回顾分析经免疫组化证实的30例GST的临床资料和病理特点。结果：CD117、CD34、SMA、S－100在GST阳性表达率分别为93.3%、90．0％、6．7％和3．3％。瘤体长径≥5.5cm、腔外或腔内外生长、存在溃疡、肿瘤坏死在恶性和潜在恶性GST中的比例分别为15／20（75.0%)、14／20（70.0%)、11／20（55.0%)、12／20（60.0%)，而良性GST中分别为2／10（20.0%)、3／10（30.0%)、2／10（20．0％）、0／10（0）。结论：胃间质瘤具有较为独特的组织学形态，结合术中综合评估其生物学特性有助于判断良恶性，并指导外科治疗。

An Analysis of the Clinicopathological Characteristics of 30 Cases of Gastric Stromal Tumor

Purpose To investigate the clinicopathologic and immunohistochemical characteristics of the gastric stromal tumors(GST).The clinicopathological data of 30 patients with GST detected by immunohistochemical technique were analysed retrospectively. Of all patients in this group, the positive rate of CD117,CD34,SMA,S-100 were 93.3%,90.0%,6.7%,3.3% respectively. Tumor diameter over 5.5cm,tumor extra growth, tumor ulcer, and tumor necrosis constituted 75.0%,70.0%,55.0%,60.0%respect ively in the 20 cases of the latent malignant or malignant GST,and those constituted 20.0%,30.0%,20.0%,0 respectively in 10 cases of benign GST.[Conclusion]GST have some special histological and morphological features.Assessing these biological characteristics during operation will give us some useful information for differentiating benign and malignant,and conducting surgical treatment.