Investigation of T2-weighted signal intensity of infarcted myocardium and its correlation with delayed enhancement magnetic resonance imaging in a porcine model with reperfused acute myocardial infarction |
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Authors: | Seong Hoon Choi Joon-Won Kang Sang-Tae Kim Byung Han Lee Eun Ju Chun Karl H Schuleri Sang Il Choi and Tae-Hwan Lim |
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Institution: | (1) Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea;(2) Department of Radiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea;(3) Asan Institute for Life Sciences, Seoul, South Korea;(4) Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gyeonggi-do, Korea;(5) Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA;(6) Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-2-dong, Songpa-gu, Seoul, 138-736, South Korea; |
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Abstract: | To assess the signal pattern in T2-weighted images (T2WI) and determine its relation to persistent microvascular obstruction
(PMO) and intramyocardial hemorrhage in a porcine model with reperfused acute myocardial infarction. Left anterior descending
artery was occluded (90 or 180 min) and reperfused (90 min). T2WI and delayed-enhanced magnetic resonance images (DE-MRI)
were acquired. The T2WI signal pattern, T2WI contrast ratio, PMO, and intramyocardial hemorrhage were evaluated, and their
interrelationships were analyzed. The infarct area on T2WI was recorded as a homogeneous high-intensity signal or as low-
or iso-intensity signals. The contrast ratio of the T2WI in the cases with PMO was significantly lower than that in those
without PMO (1.38 ± 0.25 vs. 1.89 ± 0.31, P < 0.05), and it showed significant inverse correlation with the extent of PMO observed in DE-MRI images (r =−0.8, P < 0.05). The extent of PMO correlated strongly with that of intramyocardial hemorrhage (r = 0.97, P < 0.05). The abnormal signal area in the T2WI was larger than the infarct area in the DE-MRI images (47.0 ± 9.9% vs. 37.8 ± 9.9%,
P < 0.05) and the infarct area observed after TTC staining (47.0 ± 9.9% vs. 37.4 ± 8.4%, P < 0.05). We observed variable T2WI signal patterns for the infarcted myocardium. Lower T2WI contrast ratios significantly
correlated with the extent of PMO in DE-MRI and intramyocardial hemorrhage in the gross specimen. |
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