首页 | 本学科首页   官方微博 | 高级检索  
     

抗癌中药希丹液的急性毒性作用研究
引用本文:冉文华,王贤德,余成琳,姚干. 抗癌中药希丹液的急性毒性作用研究[J]. 重庆医科大学学报, 2005, 30(4): 628-630
作者姓名:冉文华  王贤德  余成琳  姚干
作者单位:三峡中心医院,重庆,万州,404000;重庆万州中医校附属医院,重庆,万州,404000;重庆邮电学院生物信息学院,重庆,400065
摘    要:目的:研究抗癌中药希丹液的急性毒性作用.方法:小鼠灌胃(ig)给药后,测定希丹液的LD50,观察动物的协调平衡及自主活动情况.结果:小鼠ig希丹液的LID50为148.08g(生药)/kg,当ig希丹液的剂量为LD50或大于LD50[180g(生药)/kg]时,可见小鼠对机械刺激的反应降低,自主活动明显减少,小鼠的肌张力及协调平衡活动明显障碍.结论:希丹液的急性毒性作用主要表现在神经系统.

关 键 词:希丹液  毒性作用  小鼠
文章编号:0253-3626(2005)04-0628-00
修稿时间:2005-04-22

Acute toxicity of Xidan Suspensions in mice
Ran WenHua;Wang XianDe;Yu ChengLin;Yao Gan. Acute toxicity of Xidan Suspensions in mice[J]. Journal of Chongqing Medical University, 2005, 30(4): 628-630
Authors:Ran WenHua  Wang XianDe  Yu ChengLin  Yao Gan
Affiliation:Sanxia Central Hospital
Abstract:Objective:To study acute toxicity of Xidan suspensions in mice.Methods:To measure the LD50 and to observe the response to machinery stimulation and the autonomic activity of the experimental animals when Xidan suspensions is taken orally into the mice.Results:The LD_(50) of Xidan suspensions is 148.08g(crude medicinal materials)/kg in the mice by ig.When it is taken orally(ig)into the mice at the dosage of LD_(50) or more [180g(crude medicinal materials)/kg],it is found that the response to machinery stimulation,the autonomic activity the muscle tone and the regulation of balance ability decreased obviously.Conclusion:It is indicated that Xidan suspensions could be toxic to the nervous system of mice.
Keywords:Xidan suspensions   Toxicity   Mice
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号