Promoter variation in the catechol-O-methyltransferase gene is associated with remission of symptoms during fluvoxamine treatment for major depression |
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Authors: | Naoki Fukui Yutaro SuzukiTakuro Sugai Junzo WatanabeShin Ono Nobuto TsuneyamaToshiyuki Someya |
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Affiliation: | Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan |
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Abstract: | We investigated the association between remission of depressive symptoms in fluvoxamine treatment and catechol-O-methyltransferase (COMT) gene. Sixteen SNPs in the COMT gene were investigated in 123 outpatients with major depression. Three single nucleotide polymorphisms located in the 5′ region were associated with remission in fluvoxamine-treated outpatients with moderate to severe depression. |
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Keywords: | COMT Depression Fluvoxamine |
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