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Dynamics of interleukin-21 production during the clinical course of primary and secondary dengue virus infections
Authors:H. Vivanco-Cid,M.J. Maldonado-Renterí  a,L.A. Sá  nchez-Vargas,I.Y. Izaguirre-Herná  ndez,K.G. Herná  ndez-Flores,R. Remes-Ruiz
Affiliation:1. Instituto de Investigaciones Medico-Biológicas, Universidad Veracruzana, Veracruz, México;2. Hospital Regional de Alta Especialidad de Veracruz, Servicios de Salud de Veracruz, México;3. Universidad del Valle de México, campus Villa Rica, Facultad de Medicina “Dr. Porfirio Sosa Zárate”, México
Abstract:Previous studies have revealed the clinical relevance of pro-inflammatory cytokine production during dengue virus (DENV) infections. In this study, we evaluated the production of interleukin-21 (IL-21), a key soluble mediator mainly produced by CD4+ T cells.
Keywords:Dengue   Interleukin 21   Antibody response   Cellular immunity
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