芪丹益肾降糖丸治疗糖尿病肾病的临床研究

目的观察芪丹益肾降糖丸治疗糖尿病肾病（DN）的临床疗效。方法将210例DN患者随机分为2组,对照组100例予常规治疗,治疗组110例在对照组治疗基础上加服芪丹益肾降糖丸。2组均治疗3个月后统计疗效。观察2组治疗前后空腹血糖（FPG）、餐后2 h血糖（2 hPG）、糖化血红蛋白（HbAlc）、24 h尿蛋白定量2、4 h尿微量白蛋白排泄率（UAER）、血尿素氮（BUN）、血肌酐（Cr）及血脂胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）]变化情况。结果治疗组总有效率82.73%,对照组总有效率77.00%,2组比较差异有统计学意义（P〈0.05）;2组治疗后血糖水平（FPG2、hPG和HbAlc）、肾功能（24 h尿蛋白定量、UAER、BUN和Cr）及血脂（TC、TG、HDL-L和LDL-L）与本组治疗前比较差异均有统计学意义（P〈0.05）,治疗组改善情况优于对照组（P〈0.05）。结论芪丹益肾降糖丸可降低DN患者血糖,减轻蛋白尿,改善脂类代谢。

Effect of Qidanyishenjingtang pill on diabetic nephropathy

Objective To observe the effect of Qiclanyishenjingtang pill on diabetic nephropathy. Methods 210 patients with diabetic nephmpathy （DN） were randomly divided into two groups. Patients in control group （ n = 100） were treated by routine therapy. Patients in treatment group （ n = 110） were treated by condaination of Qidanyishenjingtang pill and routine therapy. The changes of FPG, 2 hPG, HblAc, 24 h urine protein, UAER, BUN, serum creatinine （Scr）, TC, TG, L1）L- C, and HDL- C were observed before and after treatment. Results The total effective rate in treatment group （ 82.73% ） was higher than that in control group（77.00%, P 〈 0.05）. There were significant difference between two groups on FPG, 2 hPG, HbAlc, 24 h urine protein, UAER, BUN, and Cr, after treatment （ P 〈 0.05）. There were significant difference between before and after treatment on TC, TG, HDL- L LDL- L in two groups （ P 〈 0.05）. Improvement of indexes in treatment group were superior to those in control group（ P 〈 0.05）. Conclusion Qidanyishenjingtang pill can decrease FPG in patient with DN, relief albuminuria and improve lipid metabolism.