高原地区幽门螺旋杆菌感染情况及其与胃癌发病的关系

目的 探讨高原地区胃癌患者幽门螺旋杆菌(HP)感染情况及其与胃癌临床特征的关系.方法 选取高原地区及平原地区胃癌患者各250例,入组对象均经电子胃镜下病理活检确诊,均行14C-尿素呼气试验测定HP感染情况,分析高原地区胃癌患者HP感染情况及其与胃癌临床特征的关系.结果 高原地区胃癌患者HP(+)率明显高于平原地区(P﹤0.01),高原地区及平原地区男性患者HP(+)率均明显高于女性患者(P﹤0.01);高原地区及平原地区年龄﹥40岁患者的HP(+)率均高于年龄≤40岁患者(P﹤0.05);高原地区HP(+)胃癌患者肿瘤部位、临床分期、浸润深度、淋巴结转移情况与HP(-)胃癌患者比较,差异有统计学意义(P﹤0.05).结论 高原地区胃癌男性患者HP感染率明显高于平原地区,HP感染可能与胃癌的发生、进展有密切的关系,应加强高原地区人群HP防治,以降低高原地区胃癌发病率.

Helicobacter pylori infection in the plateau region of China and its relationship with the pathogenesis of gastric cancer

Objective To investigate the infection rate of helicobacter pylori (HP) in patients with gastric cancer and the relationship with the pathogenesis of gastric cancer. Method 250 gastric cancer patients in plateau region and anoth-er 250 in plain region of China were enrolled in the analysis, all patients were examined by 14C-urea breath test for HP in-fection, and the correlation between HP infection and gastric cancer were analyzed. Result The rate of HP (+) in plateau region was higher than those in plain areas (P<0.01), with higher HP (+) rate observed in males of plateau region com-pared with females in plain areas (P<0.01);the HP (+) rate was consistently lower in patients aged≤40 years than those>40 years regardless of the region distribution (P<0.05);patients with HP (+) in plateau region and those with HP (-) in plain areas differed in regard of tumor sites, clinical stage, depth of invasion, and lymph node metastasis (P<0.05). Con-clusion The HP infection rate in male patients with gastric cancer in plateau region was significantly higher than that in plain areas, and HP infection may be related to the occurrence and progression of gastric cancer, so the patients in plateau region should be closely monitored for HP infection to reduce incidence of gastric cancer.