EGFR突变与肺癌伴恶性胸腔积液患者生物学行为的相关性研究

目的 探讨表皮生长因子受体(EGFR)基因突变与肺癌伴恶性胸腔积液患者生物学行为之间的关系.方法 选取肺癌患者100例,其中伴恶性胸腔积液者43例作为观察组,不伴胸腔积液者57例作为对照组,观察两组患者EGFR基因突变情况.结果 观察组EGFR总突变率为72.09%,高于对照组的19.30%(P﹤0.05);观察组高分化、中分化和低分化患者的EGFR突变率分别为69.23%、71.43%和77.78%,均高于对照组高分化、中分化和低分化患者(P﹤0.05);不同性别、年龄、吸烟情况及分化程度的观察组患者EGFR基因突变率比较,差异均无统计学意义(P﹥0.05);胸腔积液与活检组织标本EGFR基因检测结果的Kappa值为0.466(P﹤0.05),一致性中等.结论 肺癌伴恶性胸腔积液患者EGFR突变率较高,但EGFR突变与肺癌伴恶性胸腔积液患者的性别、年龄、吸烟情况及分化程度无关.

The correlation between EGFR mutation and the biological behavior of lung cancer patients with malignant pleural effusion

Objective To investigate the relationship between the mutation of epidermal growth factor receptor (EGFR) gene and the biological behavior of lung cancer patients with malignant pleural effusion. Method 100 patients with lung cancer, including 43 cases with malignant pleural effusion (study group), and 57 patients without pleural effu-sion (control group), were observed for the EGFR mutation status. Result The overall EGFR mutation rate in the study group was 72.09%, significantly higher than that of the control group at 19.30%(P<0.05);the EGFR mutation rate of pa-tients with high, moderate and low differentiation in study group was 69.23%, 71.43%and 77.78%, which were signifi-cantly higher than those in the control group, respectively (P<0.05);gender, age, smoking status and differentiation de-gree were independent of the EGFR mutation rate in study group (P>0.05);the Kappa value of the EGFR gene test results obtained from pleural effusion and biopsy specimens was 0.466 (P<0.05), indicating a moderate consistency. Conclusion EGFR mutation rate is higher in lung cancer patients with malignant pleural effusion, but is not associated with gender, age , smoking status and differentiation degree.