男性乳腺癌的临床病理特征和预后分析

目的 分析男性乳腺癌(MBC)患者的临床病理特征,并探讨影响其预后的因素.方法 对23例MBC患者的病历资料进行回顾性分析.采用Kaplan-Meier法计算患者的生存率,并对影响患者预后的危险因素进行分析.结果 23例MBC患者的发病年龄为37~82岁,中位年龄61.6岁;肿瘤平均直径为3.8 cm.全组患者的3年、5年、10年总生存率分别为84.0%、61.6%、54.8%;3年、5年、10年无病生存率分别为63.1%、51.6%、51.6%.单因素分析结果显示,TNM分期、原发肿瘤大小、腋窝淋巴结是否转移对MBC患者的5年总生存率和无病生存率均有影响(P﹤0.05);激素受体状态对MBC患者的5年生存率有影响(P﹤0.05),对MBC患者的5年无病生存率无影响(P﹥0.05).结论 TNM分期、原发肿瘤大小、腋窝淋巴结是否转移是影响MBC患者5年总生存率和无病生存率的预后因素;激素受体状态是影响MBC患者5年生存率的预后因素.早期诊断及综合治疗是延长MBC患者生存期的关键.

Male breast cancer:an analysis of clinicopathological features and prognostic factors

Objective To evaluate the clinicopathological features and prognosis of male patients with breast cancer, and to explore the prognostic factors for male breast cancer (MBC). Method The clinicopathological profiles and fol-low-up information of 23 MBC patients were retrospectively reviewed. The survival rate was calculated by Kaplan-Mei-er analysis, and the risk factors influencing patients'prognosis were determined. Result The age of onset of the 23 cas-es was 37~82 (median: 61.6); the average tumor diameter was 3.8 cm. The overall survival (OS) rates were 84.0%, 61.6%and 54.8%at 3, 5 and 10 years, and the disease-free survival (DFS) rates by Kaplan-Meier method were 63.1%, 51.6%, and 51.6% at 3, 5 and 10 years, respectively. The univariate analysis showed that TNM stage, primary tumor size, axillary lymph nodes metastases were factors influencing patients'5-year OS and DFS rates (P<0.05);while hor-mone receptor status was associated with 5-year OS rather than with 5-year DFS (P>0.05). Conclusion The TNM stag-es, tumor size and axillary lymph node status are prognostic factors of 5-year OS and DFS for MBC;while hormone re-ceptor status is a prognostic factor of 5-year DFS for MBC, and early diagnosis and comprehensive treatment are essen-tial to improve the survival of MBC.