多索茶碱持续泵入在慢性阻塞性肺疾病患者中的应用效果研究

目的探讨多索茶碱持续泵入治疗慢性阻塞性肺疾病的临床疗效和安全性。方法选择2009年2月～2012年2月在我院呼吸科治疗的112例慢性阻塞性肺疾病患者为研究对象,运用随机数字表法将本研究入选患者分为对照组和实验组,对照组患者静脉滴注多索茶碱进行治疗,而实验组患者则微量泵持续泵入进行治疗,治疗7 d,比较对照组和实验组临床疗效和药物不良反应发生率。结果治疗后,实验组患者治疗总有效率(96.43%)明显高于对照组(85.71%),实验组患者治疗后肺功能及血气分析改善显著优于对照组患者(P<0.05),但是对照组和实验组患者在不良反应发生率方面比较,差异无统计学意义(P>0.05)。结论多索茶碱持续泵入治疗慢性阻塞性肺疾病临床疗效确切,疗效优于静脉滴注,安全可靠,不良反应少。

Application effect study on patients with chronic obstructive pulmonary diseases by continuous pump into Doxofylline

Objective To investigate the clinical efficacy and safety of patients with chronic obstructive pulmonary diseases by continuous pump into Doxofylline.Methods 112 patients with chronic obstructive pulmonary diseases who were treated in the department of pneumology in our hospital from February 2009 to February 2012 were chosen as subjects,then pa tients were divided into the control group and observation group by using a random number table,patients in the control group were given Doxofylline by intravenous drip,while the observation group were given Doxofylline by continuous pump,the clinical efficacy and adverse drug reaction rate of each group was evaluated after seven days.Results The total clinical efficient rate in the observation group was higher than that in the control group（96.43% vs 85.71%,P〈0.05）,and pulmonary function and blood gas analysis in the observation group were better than that in the control group（P〈0.05）,but there was no significant difference between the two groups（P〉0.05）.Conclusion Chronic obstructive diseases by continuous pump into Doxofylline can obtaine satisfactory curative effect for patients with chronic obstructive pulmonary diseases,superior to the intravenous drip,and it is safe and reliable.