| 骨肉瘤化疗耐药机制及逆转治疗的研究进展 |
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| 引用本文： | 张燕,张俐,牛素生,刘俊宁. 骨肉瘤化疗耐药机制及逆转治疗的研究进展[J]. 中国医药导报, 2012, 0(32): 23-25 |
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| 作者姓名： | 张燕 张俐 牛素生 刘俊宁 |
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| 作者单位： | 福建中医药大学骨伤学院,福建福州350108 |
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| 基金项目： | 国家自然科学基金（青年项目）（项目名称：片仔癀对骨肉瘤多药耐药性影响的实验研究;批准号：30901916） |
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| 摘 要： | 骨肉瘤是常见的骨源性恶性肿瘤,化疗是其重要的治疗手段,但肿瘤耐药性的存在,成为骨肉瘤复发和治疗失败的重要原因。明确其耐药机制,有效预防或逆转骨肉瘤耐药是目前临床亟待解决的问题。本文将对骨肉瘤耐药机制及其逆转策略的研究进展作一综述。
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| 关 键 词： | 骨肉瘤 耐药机制 逆转 |
Research progress of drug resistance mechanism on osteosarcoma chemotherapy and reverse treatment |
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| ZHANG Yan,ZHANG Li,NIU Susheng,LIU Junning. Research progress of drug resistance mechanism on osteosarcoma chemotherapy and reverse treatment[J]. China Medical Herald, 2012, 0(32): 23-25 |
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| Authors: | ZHANG Yan ZHANG Li NIU Susheng LIU Junning |
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| Affiliation: | College of Orthopedics,Fujian University of Traditional Chinese Medicine,Fujian Province,Fuzhou 350108,China |
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| Abstract: | Osteosarcoma is a sort of malignant commonly-seen osteogenic sarcomas,a better treatment for it is chemother apy.However,tumor drug resistance is a key factor causing recurrence of osteosarcoma and treatment failure.Therefore,clearly understand its drug resistance mechanism and further effectively prevent or reverse osteosarcoma＇s drug resistance are urgent problems needed to be solved in current clinic.The article is going to review on drug resistance mechanism of osteosarcoma and strategy for its reversal. |
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| Keywords: | Osteosarcoma Drug resistance mechanism Reverse |
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