| 食管鳞癌组织中hPOT1、hTERT及p53的表达 |
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| 引用本文： | 孙瑞清,吴建农,殷瑞根,成静. 食管鳞癌组织中hPOT1、hTERT及p53的表达[J]. 江苏医药, 2008, 34(9): 865-866 |
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| 作者姓名： | 孙瑞清 吴建农 殷瑞根 成静 |
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| 作者单位： | 江苏大学医学院病理学教研室,镇江,212013;江苏大学附属医院病理科;江苏大学医技学院 |
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| 基金项目： | 江苏省教育厅自然科学基金 |
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| 摘 要： | 目的 探讨食管鳞癌组织中端粒保护蛋白1(hPOT1)、端粒酶催化亚基(hTERT)及p53的表达及其意义.方法 采用免疫组织化学技术检测82例食管鳞癌组织中hPOT1、hTERT及p53的表达情况.结果 82例鳞癌组织中,hPOT1蛋白阳性表达率为78.05%(64/82),hTERT蛋白阳性表达率为68.29%(56/82),p53蛋白的阳性表达率为65.85%(54/82),它们与淋巴结转移、病理分期密切相关(P＜0.05).结论 联合检测hPOT1、hTERT及p53蛋白的表达对判断食管鳞癌的预后有一定的指导意义.
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| 关 键 词： | 食管鳞癌 端粒保护蛋白1 端粒酶催化亚基 p53 |
Expressions of hPOT1,hTERT and p53 in esophageal squamous cell carcinoma |
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| SUN Ruiqing,WU Jiannong,YIN Ruigen,et al.. Expressions of hPOT1,hTERT and p53 in esophageal squamous cell carcinoma[J]. Jiangsu Medical Journal, 2008, 34(9): 865-866 |
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| Authors: | SUN Ruiqing WU Jiannong YIN Ruigen et al. |
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| Affiliation: | SUN Ruiqing,WU Jiannong,YIN Ruigen,et al.Department of Pathology,Medical College,Jiangsu University,Zhenjiang 212001,CHINA |
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| Abstract: | Objective To investigate the expression and clinical significance of hPOT1,hTERT and p53 in esophageal squamous cell carcinoma tissues.Methods Immunohistochemical technique was used to detect the expression levels of hPOT1,hTERT and p53 in esophageal squamous cell carcinoma.Results The positive expression rates of hPOT1,hTERT and p53 in esophageal squamous cell carcinoma tissues were 78.05%(6482),68.29%(5682) and 65.85%(5482),respectively.They were significantly correlated with lympha metastasis and patholo... |
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| Keywords: | p53 |
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