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Moderate alcohol consumption predicts long-term mortality in elderly subjects with chronic heart failure
Authors:G Gargiulo  G Testa  F Cacciatore  F Mazzella  G Galizia  D Della-Morte  A Langellotto  G Pirozzi  G Ferro  N Ferrara  F Rengo  Pasquale Abete
Institution:1. Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Cattedra di Geriatria, Università degli Studi di Napoli “Federico II”, Naples, Italy
2. AON, SS Antonio e Biagio e Cesare Arrigo, Struttura Complessa di Geriatria, Alessandria, Italy
3. Dipartimento di Medicina e Scienze della Salute, Università del Molise, Campobasso, Italy
4. Istituto Scientifico di Campoli/Telese, Fondazione Salvatore Maugeri, IRCCS, Benevento, Italy
5. Istituto Scientifico di Veruno, Fondazione Salvatore Maugeri, IRCCS, Veruno (NO), Italy
6. Department of Advanced Biotechnologies and Bioimaging, IRCCS San Raffaele, Rome, Italy
7. Dipartimento di Medicina Clinica e Scienze Cardiovascolari ed Immunologiche, Cattedra di Geriatria, University of Naples Federico II, 80131, Napoli, Italy
Abstract:

Objective

Moderate alcohol consumption is related to a reduction of mortality. However, this phenomenon is not well established in the elderly, especially in the presence of chronic heart failure (CHF). The aim of the study was to verify the effect of moderate alcohol consumption on 12-year mortality in elderly community-dwelling with and without CHF.

Settings

community-dwelling from 5 regions of Italy.

Participants

A cohort of 1332 subjects aged 65 and older.

Measurement

Mortality after 12-year follow-up in elderly subjects (≥65 years old) with and without CHF was studied. Moderate alcohol consumption was considered ≤250 ml/day (drinkers).

Results

In the absence of CHF (n=947), mortality was 42.2% in drinkers vs. 53.7% in non-drinker elderly subjects (p=0.021). In contrast, in the presence of CHF (n=117), mortality was 86.5% in drinkers vs. 69.7% in non-drinker elderly subjects (p=0.004). Accordingly, Cox regression analysis shows that a moderate alcohol consumption is protective of mortality in the absence (HR=0.79; CI 95% 0.66–0.95; p<0.01) but it is predictive of mortality in the presence of CHF (HR=1.29; CI 95% 1.05–1.97; p<0.05).

Conclusions

Our data demonstrates that moderate alcohol consumption is associated with an increased long-term mortality risk in the elderly in the presence of CHF.
Keywords:
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