Prevalence ofHelicobacter pylori resistance to several antimicrobial agents in a region of Germany |
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Authors: | K Wolle M Nilius A Leodolter W A Müller P Malfertheiner W König |
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Institution: | (1) Institute of Medical Microbiology, Otto-von-Guericke University Magdeburg, Leipziger Straße 44, D-39120 Magdeburg, Germany;(2) Department of Gastroenterology, Hepatology, and Infectious Diseases, Otto-von-Guericke University Magdeburg, Leipziger Straße 44, D-39120 Magdeburg, Germany |
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Abstract: | To evaluate the prevalence of resistance amongHelicobacter pylori in Germany, the minimum inhibitory concentrations of amoxicillin, tetracycline, clarithromycin, and metronidazole were determined by means of the E test, for 271Helicobacter pylori isolates cultured from biopsies taken during routine endoscopies in 1996 and 1997. The prevalence of metronidazole resistance was 32.1%, with resistance found more frequently in women (38.5%) than in men (24.4%). Clarithromycin resistance was rare (3.3%). Eight of nine strains resistant to clarithromycin were also resistant to metronidazole. Resistance to either metronidazole or clarithromycin was significantly (P=0.022) higher in patients with duodenal ulcer. No strain was found to be resistant to amoxicillin or tetracyline. |
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