肺癌癌基因产物C－FOS、C－JUN、Phosphotyrosine表达的研究

对９７例肺癌进行了癌基因产物Ｃ－ＦＯＳ、Ｃ－ＪＵＮ、Ｐｈｏｓｐｈｏｔｙｒｏｓｉｎｅ（以下称Ｐ－Ｔｙｒ）的免疫组织化学研究。结果表明：其表达率为Ｃ－ＦＯＳ＜ＣＪＵＮ＜ｐ－Ｔｙｒ。上述三者均可在核、核膜及细胞质内表达。正常支气管、肺组织Ｃ－ＦＯＳ表达分别占３．８％及１．６％。而在肺癌、Ｃ－ＦＯＳ表达占６０％。Ｃ＋ＦＯＳ及Ｃ－ＪＵＮ同时阳性的５４例（５６％），Ｃ－ＦＯＳ阴性，而Ｃ－ＪＵＮ阳性的３１例（３２％）。Ｃ－ＦＯＳ阳性、Ｃ－ＪＵＮ阴性的４例（４％），两者同时阴性的８例（８％）。虽然Ｃ－ＦＯＳ与Ｃ－ＪＵＮ通过拉锁构造形成杂二聚体，但Ｃ－ＦＯＳ也可单独表达。

The expresslon of C-FOS,C-JUN and phosphotyrosine gene products in lung cancer

n immunohistochemical study on C-FOS,C-JUN and phosphotyrosine( p-Tyr)cancer gene products was performed. The resuIts showed that C-FOS had the lowest frequency of expression and P-Tyr had the highest.The positive reactions of the three cancer gene products were observed in the nucleus nuclear membrane and cytoplasm, The expression of C-FOS in normal bronchial and alveolar tissue was 3.8%and 1.6%respectively. But in lung cancer it was 60%, The simultaneous positive expression of C-FOS and C-JUN was 56%(54 cases).Negative C-FOS and positive C-JUN was 32%. Positive C-FOS and negative C-JUN was less than 4%(4 cases).Although C-FOS and C-JUN formed a hetero-dimer by zipper structure, the C-FOS had the ability of single expression.